Metabolic stability cell viability

Radical attack of nucleic bases in DNA and RNA results in their hydroxylation, disorders their regular package and decreases stability of the macromolecules with subsequent fragmentation. Actually, in cells with marked oxygen metabolism oxidative modification of nucleic acids takes place in amount exceeding ten thousand hits a day [5]. However, most of them have no after-effects for cell viability demonstrating the presence of specific cellular antioxidant defense repare system. 

Studies on Thermotoga maritima have been focusing mainly on evolution, metabolism, and the correlation of protein structure and stability. It has been established that viability of the hyperthermophile in its hostile natural habitats is based on the inherent thermostability of its whole cell inventory. In some cases this is assisted by extrinsic components such as the cell membrane or specific ligands and compatible solutes. As a response to short-term temperature... 

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