Metabolic markers

Lentz MR, Westmoreland SV, Lee V, Ratal EM, Halpem EF, Gonzalez RG (2008) Metabolic markers of neuronal injury correlate with SIV CNS disease severity and inoculum in the macaque model of neuroAlDS. Magn Reson Med 59(3) 475-484 Letendre SL, Lanier ER, McCutchan JA (1999) Cerebrospinal fluid beta chemokine concentrations in neurocognitively impaired individuals infected with human immunodeficiency virus type 1. J Infect Dis 180(2) 310-319... 

Orlistat induces weight loss by lowering dietary fat absorption, and it also improves lipid profiles, glucose control, and other metabolic markers. Soft stools, abdominal pain or colic, flatulence, fecal urgency, and/or incontinence occur in 80% of individuals, are mild to moderate in severity, and improve after 1 to 2 months of therapy. Orlistat interferes with the absorption of fat-soluble vitamins and cyclosporine. 

Paul, N., Do Eating Patterns and Post-Prandial Hormonal and Metabolic Markers Vary Significantly According to Shift Type and Circadian Status in Swing Shift Workers in the Offshore Oil Industry, BSc Thesis, University of Surrey, 2001. 

Choose method and schedule for blood collection. Common survival blood collection methods for metabolic profiling are tail-nick, tail snip, saphenous vein, submandibular (cheek), and retroorbital bleeding. With the tail nick or tail snip blood collection methods, 75 pi samples of blood can be collected up to four times in a 1-day experiment, not exceeding a total of 250 pi, and are used as default blood collection procedures. This usually provides up to 30 pi serum samples and is sufficient to measure glucose, insulin, and other metabolic markers. In some cases, larger... 

Terminal blood collection is often performed upon completion of an experiment, as it is useful to perform measurements of additional metabolic markers on cohorts that showed compound... 

Wienkers LC, Wurden CJ, Storch E, et al. Formation of (R)-8-hydroxywarfarin in human liver - microsomes - a new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19. Drug Metab Dispos 1996 24 610-614. 

A small number of patients show one or the other of the biochemical signs associated with vitamin Be deficiency despite apparendy adequate status, and require high intakes of the vitamin to normalize the abnormal metabolic marker. These are genetic diseases and have been termed vitamin Be dependency syndromes. 

Appel, N.M., Rapoport, S.I., O Callaghan, J.P., Bell, J.M., and Freed, L.M. 1997b. Sequelae of parenteral domoic acid administration in rats comparison of effects on different metabolic markers iuhrain. Brain Res 754, 55-64. 

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