Ischemia stress-induced

Currie, R.W. (1987). Effects of ischemia and perfusion temperature on the synthesis of stress-induced (heat shock) proteins in isolated and perfused rat hearts. J. Mol. Cell. Cardiol. 19, 795-808. 

Shattock, M.J., Hearse, D.J. and Matsuura, H. (1990). Ionic currents underlying orudant stress-induced arrhythmias. In Ionic Currents and Ischemia (eds. J. Vereecke, P.P. van... 

Figure 2.6 illustrates stunned myocardium with normal resting perfusion but a severe stress induced perfusion defect that indicates severe ischemia in the distribution of the RCA and the LAD proximal to the first septal perforator. Metabolic imaging with FDG is not necessary, since resting perfusion is normal without scar with a left ventricular ejection fraction (LVEF) of 30% thereby indicating stunned myocardium that normalized after bypass surgery. This patient with severe stress induced ischemia and reduced LV function characteristic of stunned myocardium contrasts with the patient of Fig. 2.2 with severe ischemia but normal LV function and no stunning. 

It is clear that under in vitro assay conditions, anthocyanins can function as antioxidants. However, in vivo, anthocyanin absorption appears to be low. In animal models, dietary anthocyanins at relatively high doses (1 to 2 mg/kg diet) are protective against oxidative stress induced in a number of models, including ischemia reperfusion, paraquat, CCL4, and t-BHP. In humans, anthocyanins appear to have some vasopro-tective effects, but whether these are the result of antioxidant mechanisms is not clear. It appears that in most of the studies reviewed, the dose of anthocyanins was well above that which might be normally consumed in the diet with natural foods, except for perhaps one study in which 1 cup of blueberries was consumed for 30 days and small increases in plasma antioxidant capacity were observed." ... 

Heat stress induced cross tolerance to myocardial ischemia... 

Udelson et al.87 Ph I, open label, (dose escalation) ic, iv 0.33-48 59 ETT stress-induced ischemia, resting myocardial perfusion... 

Mukherjee, P. K. Ahamed, K. F. H. N. Kiunar, V. Mukherjee, K. Houghton, P. J., Protective efiect of biflavones from Araucaria bidwillii Hook in rat cerebral ischemia/reperfiision induced oxidative stress, Behav. Brain Res., 2007, 178, 221-228. 

Sharir T, Germano G, Kang X, et al. Prediction of myocardial infarction versus cardiac death by gated myocardial perfusion SPECT Risk stratification by the amount of stress-induced ischemia and the poststress ejection fraction. / Nucl Med 2001 42(6) 831-7. 

---