Merck Frosst Canada

The author thanks Dr. Christopher Bayly from Merck Frosst Canada for his initial important contribution to GLARE and for a careful proofreading of this chapter. 

Bayly, C. I., Black, W. C., Ouimet, N., Percival, M. D., Leger, S., Ouellet, M. Biaryl-acetic acid derivatives and their use as COX-2 inhibitors (Merck Frosst Canada Inc.), WO 9941224,1999. 

Funding for the conference came from the divisions of inorganic chemistry of the American Chemical Society (ACS) and the Chemical Institute of Canada, the Petroleum Research Fund (ACS), the Natural Sciences and Engineering Research Council, York University, and eight industrial companies Strem Chemicals Inc. Merck Frosst Canada Inc. Union Carbide Canada Limited EG G Canada Limited Xerox Research Centre of Canada Tasman Scientific Inc. Guided Wave, Inc. and Lumonics Inc. 

Department of Clinical Sciences, Merck Research Laboratories, Merck Co., Inc., Rahway, New Jersey and tDepartment of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada Co., Kirkland, Quebec, Canada... 

B. Cote etal, US Patent 6,639,077 (October 28, 2003) Assignee Merck Frosst Canada Co. 

Merck Frosst Canada and Company, Pointe Claire-Dorval, Quebec, Canada... 

As mentioned above, the title compounds are now known to constitute the active components of SRS-A, and as such have been the subject of intense biological and synthetic research. All the syntheses of these thioether structures have converged on LTA4 methyl ester, the various syntheses of which were outlined in Section 3.C. Three groups, that of Corey at Harvard University, the Merck Frosst Canada group, and workers at Hoffmann-La Roche, independently developed synthetic routes to LTA4 methyl ester and hence to various components of the SRS-A complex. 

Research Library and Information Centre, Merck Frosst Canada Co.,... 

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