Merck Frosst

M826 Merck-Frosst Caspase-3 and -7 (reversible) IC50 0.006 jM (C-3) IC50 0.042 pm (C-7) Huntington s disease Pre-din ical... 

A patent application from Merck Frosst, published in 1997, discloses CB2 selective compounds with modified core structures where the pyran oxygen is replaced by nitrogen, such as (342), which has a K of around 64 nM at CB2 and around 25,000 nM at CBi [217]. 

Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada H9H 3L1... 

We are grateful to the Canada Research Chair (Tier I) foundation (to CJL), the CFI, NSERC, Merck Frosst and CIC(AstraZeneca/Boehringer IngeUieim/Merck Frosst) for support of our research. 

The author thanks Dr. Christopher Bayly from Merck Frosst Canada for his initial important contribution to GLARE and for a careful proofreading of this chapter. 

Synthesis A number of synthetic strategies to the COX-2 specific inhibitor etoricoxib have been described (Dube et al. (Merck Frosst), 1998 Davies et al., 2000 Sobera et al., 2001a). In schemes 17-20 the two major routes via a dichloropyridine derivative or a ketosulfone, respectively, as the key intermediates are discussed. 

Bayly, C. I., Black, W. C., Ouimet, N., Percival, M. D., Leger, S., Ouellet, M. Biaryl-acetic acid derivatives and their use as COX-2 inhibitors (Merck Frosst Canada Inc.), WO 9941224,1999. 

Funding for the conference came from the divisions of inorganic chemistry of the American Chemical Society (ACS) and the Chemical Institute of Canada, the Petroleum Research Fund (ACS), the Natural Sciences and Engineering Research Council, York University, and eight industrial companies Strem Chemicals Inc. Merck Frosst Canada Inc. Union Carbide Canada Limited EG G Canada Limited Xerox Research Centre of Canada Tasman Scientific Inc. Guided Wave, Inc. and Lumonics Inc. 

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