Mercaptoethanal

Chemical Name 2-Mercaptoethane sulfonic acid sodium salt Common Name —... 

Ajmal, N. et al. The effectiveness of sodium 2-mercaptoethane sulfonate (Mesna) in reducing capsular formation around implants in a rabbit model. Blast. Reconstr. Surg., 112, 1455, 2003. 

To accomplish these reactions a surprising variety of specialized cofactors are needed.351 352 434 The first of these, coenzyme M, 2-mercaptoethane sulfonate, was discovered in 1974.436 It is the simplest known coenzyme. Later, the previously described 5-deazaflavin F420 (Section B), a nickel tetrapyrrole F430 (Chapter 16), methanopterin (Fig. 

For the thiophen mentioned above, all the carbon atoms stemmed from cysteine, carbohydrate apparently not having a role. On the other hand, theoretically, thiophens can be derived from furans simply by reaction with H2S. Belitz and Grosch251 postulate derivation from 2-mercaptoethanal (Strecker aldehyde from cysteine) and acrolein or butenal (aldol condensation product from acetaldehyde). Vemin and Parkanyi216... 

Ehrlich RM, Freedman A, Goldsobel AB, et al. 1984. The use of sodium 2 -mercaptoethane sulfonate to prevent cyclophosphamide cystitis. U Urol 131 960-962. 

Henslee PJ, Parr MD, Romond EH, et al. 1988. A randomized trail to determine the prophylactic benefit of 2-mercaptoethane sulfonate (MESNA) as a uroprotector in bone marrow transplantation (BMT) [Abstract], Proc Ann Meet Am Soc Clin Oncol 7 A1155. 

Hemorrhagic cystitis and bladder cancer are well-known complications of cyclophosphamide. The damage to the urinary bladder epithelium is caused by acrolein, a metabolite of cyclophosphamide that is excreted in the urine. In bone marrow transplant recipients, prior administration of busulfan, which itself causes hemorrhagic cystitis, can increase this risk (23). Mesna (2-mercaptoethane sodium sulfonate) is used to prevent this adverse effect. It is excreted by the kidney, and it binds and detoxifies acrolein in the urine mesna also prevents the breakdown of acrolein precursors. Intravesical prostaglandin E2 has been suggested as an alternative treatment (23). 

Methylmercuric hydroxide is very toxic and should not be used if it can be avoided. This denaturant reacts with the RNA, before electrophoretic fractionation, primarily with the imino groups of uridine and guanosine (Gruenwedel and Davidson, 1966 Bailey and Davidson, 1976) and electrophoresis is carried out in the presence of methylmercuric hydroxide. Sulfhydryl compounds (2-mercaptoethan-ol, DTT) can be used to displace methylmercuric hydroxide from imino groups. Methylmercuric hydroxide is not only extremely toxic but also volatile and should be handled in chemical hoods. All waste should be disposed of as toxic material (Junghans, 1983). 

Each reaction mixture contained Tris-maleate, (pH 7.0), 5 ymol GDP-D-(l C) mannose, 25 nmole MnCl2, 1.5 ymol 2-mercaptoethan-ol, 0.3 ymol peptidophosphogalactomannan, 3 mg and membrane preparation, 150 yg. Incubations were carried out at 25°C for indicated interval, and the reaction stopped by heating at 100°C for 2 min. The low molecular weight substances were removed by dialysis. Each sample was treated with 0.5 M NaOH for 24 hr, neutralized and chromatographed on paper and the radioactivity in the polysaccharide and oligosaccharide peaks determined. 

The potential protective effect of 2-mercaptoethane sulfonate, which reduces oxidative stress by increasing free thiols in the kidney, on renal toxicity and carcinogenicity induced by ochratoxin A has been examined in a long-term rat study. 2-Mercaptoethane sulfonate significantly reduced karyomegaly but did not reduce the incidence of renal tumours (Pfohl-Leszkowicz Manderville, 2007). 

Ethylene TMoglycol (Mercaptodhyl alcohol, thioethylene glycol, nydroxyethyl mercaptan, 1-hydroxy-2-mercaptoethane, thioglycol)... 

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