Mer — Met

Native Hez-PBAN underwent oxidation of its two methionines during the course of its isolation and purification. Oxidation of methionine to methionine sulfoxide is known to occur during the isolation of peptides and proteins from natural sources (15, 16). It was observed that purified samples of synthetic Hez-PBAN were easily oxidized to a mixture of oxidation products resulting from the oxidation of Mer and/or Met to their respective sulfoxides. These observations are consistent with the isolation of Hez-PBAN from the PBAN II zone. We speculate that the continuum of biologically-active HPLC fractions observed between 44 and 52 min after RP-HPLC Step A, represents Hez-PBAN (PBAN III), a mixture of Hez-PBAN monosulfoxides (PBAN II), and Hez-PBAN disulfoxide (PBAN I), all of which were biologically active. 

The first term on the right-hand side of Eq, (44) represents the desorption rate of a j-mer radical and the last term expresses the absoiption rate ofj-mer radicals from the water phase into the particles containing no /-met radicals. Rewriting Eq, (44) we get... 

Hez-PBAN Leu-Ser- Aso-Aryi-Met-Prti-Aia-Thr-Pro-Ala-Asp-Gln-Calo-Met-Tyr-AfB-Gln-Boam-PBAN Leo- ser-Giu-Asp-Met-Pro-Ala-Thr-Pro-Aia-Aso-Gm-Glue-Mer-Tyr-Gln-Pro-LyO-PBAN Leu-Aia-Asp-Asp-Met-Pro-Ala-Thr-Met-Ala-Asp-Gin-Gla-VaJ-Try-ArB-PiOQ-... 

The 60-mers with icosahedral symmetry that are observed in many bacteria and in plants are best described as dodecamers of pentamers, although attempts to directly observe pentamer precursors of the icosahedral 60-mers have met with little success. The molecules have the shape of hollow capsids with a diameter of about 160 A and a wall thickness of about 50 A.Relatively narrow channels through the capsid wall are observed along the five-fold symmetry axes. A considerable number of X-ray structures with bound substrate and intermediate analogues define the large active site cavity. The capsid wall is rather tightly knit and it is not entirely clear how substrates and products can traverse between solvent and active sites. 

To Determine or Evaluate Cera- mics Cer- mets Chem- icals Elasto- mers Explo- sives Chem- isiry Fuels Class Inks Metals Min- erals Paints Pharma- ceuticals Phos- phors Plas- tics Propel- lents Soaps Soils Tex- tiles... 

Table 4.4-4 provides performance criteria needed to demonstrate that the functional requirements for the Zone 1 and Zone 2A ventilation exhaust systems are met No operational events can affect the ability of the HEPA and charcoal filters to perform their safety functions, since these functions ahe only required when the HCF ventilation system is operating. Furthermore, failure of filter bank inlet or outlet dampers to remain open during ventilation system operation will essentially stop the flow of Zone 1/Zone 2A exhaust air to the HCF stack. The only events that could affect the ability of the charcoal filters to perform their safety function are a fire in the MER or an external event such as an earthquake or aircraft crash that would destroy the MER. The only events that could affect the ability of the HEPA filters to perform their safety function are similar events. 

Brabec, C.J., et al. 2001. Organic photovoltaic devices produced from conjugated poly-mer/methanofullerene bulk heterojunctions. Synth Met 121 1517. 

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