Memory disorders

In summary, the steadily increasing size of geriatric populations in developed countries and the resultant increases in age-related diseases of the brain have provided the impetus for intensive study of the processes underlying neurodegeneration. A better understanding of these processes will likely lead to better methods of treatment not only for progressive memory disorders such as Alzheimer disease, but also for motor disorders such as amyotrophic lateral sclerosis, and cerebrovascular disorders such as stroke. 

Pre-clinical data support the potential application of CBi antagonists in the treatment of various other conditions. These include memory disorders [379], sexual dysfunction [380], neuro-inflammation [381] and asthma [382]. 

Suggested Alternatives for Differential Diagnosis Meningitis, basilar artery blood clots (thrombosis), cardioembolic stroke, cavernous sinus syndromes, cerebral venous blood clots (thrombosis), confusional states and acute memory disorders, epileptic and epileptiform encephalopathies, febrile seizures, haemophilus meningitis, intracranial hemorrhage, leptomeningeal carcinomatosis, subdural pus (empyema), or bruise (hematoma). 

These drugs were developed before levodopa which has largely replaced them, probably because of a lack of modern clinical research. Actually, the adverse effects of anticholinergic drugs (confusion, memory disorders, peripheral anticholinergic effects) and the interindividual variability of their effects considerably limit their use, particularly in subjects over 65 years of age. These compounds are considered to be effective against tremor and are... 

LEARNING AND MEMORY DISORDERS NEUROGHEMIGAL PATHOLOGY IN DEMENTIA... 

Jolles J Vasopressin-hke peptides and the treatment of memory disorders in man. Prog Brain Res 60 169-182, 1983... 

Several lines of evidence suggest a role for Hj receptors in cognitive processes. The use of Hj antagonists in learning and memory disorders has been suggested. Thioperamide, a prototypic Hj antagonist, enhances arousal patterns in cats, an observation which has been confirmed using other nonthiourea Hj blockers. 

Observations of patients treated with lithium for 10 years or more have provided the somewhat comforting finding that, even after long-term treatment, these individuals did not show memory disorders going beyond the expected age-related changes (Engelsmann et al., 1988). 

It is indicated in cognitive, behavioural and somatic symptoms associated with cerebral decay, parkinson s disease, memory disorders, apathy, asthenia, anorexia, dizziness and tinnitus. 

Wernicke-Korsakoff syndrome is a relatively uncommon but important entity characterized by paralysis of the external eye muscles, ataxia, and a confused state that can progress to coma and death. It is associated with thiamin deficiency but is rarely seen in the absence of alcoholism. Because of the importance of thiamine in this pathologic condition and the absence of toxicity associated with thiamine administration, all patients suspected of having Wernicke-Korsakoff syndrome (including virtually all patients who present to the emergency department with altered consciousness, seizures, or both) should receive thiamine therapy. Often, the ocular signs, ataxia, and confusion improve promptly upon administration of thiamine. However, most patients are left with a chronic disabling memory disorder known as Korsakoff s psychosis. 

Kidney-essence and nourish the blood. They treat weakness and stiffness of the back and knees, blurred vision, poor memory, disorders of menstruation, infertility, menopause syndrome and sexual disorders caused by deficiency of Kidney-essence and blood. 

In the October 10, 1988 issue of Chemical Engineering News there appeared a brief report from the Israel Institute for Biological Research about an acetylcholine analog, cis-2-methylspiro(1,3-oxathiolane-5,3 )quinuclidine, which seems to be very specific for brain Ach receptors involved in AD. In the same report another drug in Phase I clinical trials was mentioned. Produced by Bristol-Myers it is meant to be used for a variety of cognitive memory disorders including AD. 

To discuss how memory disorders, including Alzheimer s disease, impact cholinergic neurotransmission. 

Clinical application of HA Hs receptor antagonists in learning and memory disorders... 

Age-associated memory Disorder alleged to occur in those over 60 years of age in the absence of clinical evidence of dementia. 

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