Phosphoinositides membrane trafficking

S Additional information <4, 8> (<8> the class II phosphoinositide 3-ki-nase C2a is activated by clathrin and regulates clathrin-mediated membrane trafficking [9] <4> TNFa and leptin stimulate the a-isoform of class II phosphoinositide 3-kinase [5] <8> PI3K-C2cr and PI3K-C2/1 represent two downstream targets of the activated epidermal growth factor... 

Cullen, P.J., Cozier, G.E., Banting, G. and Mellor, H., 2001, Modular phosphoinositide-binding domains - their role in signalling and membrane trafficking. Curr. Biol. 11 R882-R893. 

Martin, T.F.J., 1998, Phosphoinositide lipids as signaling molecules Common themes for signal transduction, cytoskeletal regulation, and membrane trafficking. Anna. Rev. Cell Dev. Biol. 14 231-264. 

Wurmser, A.E., Gary, J.D. and Emr, S.D., 1999, Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways. J. Biol. Chem. 274 9129-9132. 

The role of phosphoinositides has been thoroughly described in many signaling and membrane trafficking events but their function as modulators of membrane structure and dynamics in membrane fusion has not been studied. Researchers have reconstructed models that mimic the component of nuelear envelope precursor membranes with naturally elevated amaounts... 

The intracellular membranes also contain functional pools of phosphoinositides together with their metabolizing enzymes, and may play a key role as regulators of membrane trafficking (De Camilli et al., 1996). 

Odorizzi, G, Babst, M and Emr, SC (2000) Phosphoinositide signaling and the regulation of membrane trafficking in yeast Trends Biochem Sci, 25, 229-235. 

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