Membrane Surface Charge

UF is believed to reject principally on a size exclusion basis. However, as described later, the 3 kDa and 5 kDa membranes have a very similar rejection for the charged organic molecules. This can be attributed to charge interactions, as the 5 kDa membrane has the higher charge. 

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Seelig, A., Allegrini, P. R. and Seelig, J. (1988). Partitioning of local anesthetics into membranes surface charge effects monitored by the phospholipid head-group, Biochim. Biophys. Acta, 939, 267-276. 

B. Ehrenberg, Spectroscopic methods for the determination of membrane surface charge density, Methods Enzymol. 127, 678-696 (1986). 

J. Barber, Membrane surface charges and potentials in relation to photosynthesis, Biochim. Biophys. Acta 594, 253-308 (1980). 

R. Kramer, Interaction of membrane surface charges with the reconstituted ADP/ATP-carrier from mitochondria, Biochim. Biophys. Acta 735, 145-159 (1983). 

DOPC and other PCs are also used as helper lipids, mainly for dilution of the membrane surface charge. 

J.S. D Arrigo, Screening of membrane surface charges by divalent cations an atomic representation, Am. J. Physiol. 235 (1978) 109-117. 

Figure 6.15 Effect of membrane surface charge on ultrafiltration flux decline. These membranes were used to ultrafilter cathodic electrocoat paint, which has a net negative charge. Electrostatic repulsion made the negatively charged membrane significantly more resistant to fouling than the similar positively charged membrane [13]...

Afonso, M.D., Hagmeyer, G., and Gimbel, R., Streaming potential measurements to assess the variation of nanofiltration membrane surface charge with the concentration of salt solutions, Separ. Purl Tech., 22, 529, 2001. 

Zhang, Q., Smith, F.A., Sekimoto, H., Reid, R.J., 2001. Effect of membrane surface charge on nickel uptake by purified mung bean root protoplasts. Planta 213, 788-793. 

C. Bellona, J. Drewes, The role of membrane surface charge and solute physicochemical properties in the rejection of organic acids by NF membranes. Journal of Membrane Science 2005, 249, 227-234. 

FIGURE 1. Schematic representation of the fluid-mosaic model of a cell membrane showing protein molecules incorporated into a lipid bilayer structure. Lateral diffusion of the proteins and lipid molecules occurs, but the lipids very rarely migrate from one side of the membrane to the other. A transmembrane electrical field arises from the action of vectorial ion pumps (ATPase proteins) in producing ionic concentration differences across the membrane, and from the presence of membrane surface charges. Surface redox reactions may affect this membrane field. 

The Boltzmann equation (9) results from the equilibrium condition that the electrochemical potential of charged species must be the same at any distance from the membrane, provided the membrane surface charge is... 

We have considered here some of the physical factors involved in ion, electron, and proton transport in membrane structures, as well as the electric fields and electrical double layers that are intimately associated with these transport processes. In considering the membrane potential, which more accurately should be termed the transmembrane potential drop, it can be seen that the presence of membrane surface charges may be significant and could produce effects not expected from a consideration of Nernstian diffussion processes alone. For example, from Eq. (3) and the... 

R. H. Brown, Membrane Surface Charge Discrete and Uniform Modelling, Progr. 

Role of Membrane Surface Charge in Modulating Cooperative Responses to External Stimuli... 

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