Membrane transporter proteins

Hicke, L. and Dunn, R. Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins, Annu Rev Cell Dev Biol 2003, 19, 141-172. 

Lanyi JK, Schobert B. Local-global conformational coupling in a heptahelical membrane protein transport mechanism from crystal structures of the nine states in the bacteriorhodopsin photocycle. Biochemistry 2004 43 3-8. 

Two properties of lysosomal membrane are especially interesting. First, cer- fp tain membrane proteins transport protons across the membrane, thus creating the required acidic environment within the lysosomes. Second, under certain circumstances lysosomal enzymes leak into other parts of the cell. Such an occurrence... 

Carrier integrated cell membrane protein transporting small molecules, macromolecules or ions via the membrane. 

Uniporter a special type of carrier, channel or membrane protein. Transports a single substance with a solute gradient without the involvement of additional substances. 

The penetration of ammonium and amino acids into the yeast cell activates numerous membrane proteinic transporters or permeases (Section 1.3.2). S. cerevisiae has at least two specific ammonium ion transporters (Dubois and Grenson, 1979). Then-activity is inhibited by several amino acids, in a non-competitive manner. 

Oriented solid-state NMR spectroscopy and biochemical cross-linking experiments were used to show that the ligand-free membrane protein transporter EmrE forms anti-parallel dimers with different monomer tilt angles relative to the lipid bilayer. In addition, subtle conformational changes were detected upon drug binding that emphasize the need for an atomic-resolution structure. ... 

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