Membrane inhaler

NOC1 is intensely irritating to the eyes, skin and mucous membranes. Inhalation can cause pulmonary edema and hemorrhage (Ref 3) Refs 1) J.R. Morton H.W. Wilcox, Inorg-Synth 4 (1953), 48 2) Anon, C EN 35 (43),... 

Iodine vapors are an irritant to eyes, nose and mucous membranes. Inhalation can cause headache, irritation, and congestion of lungs. Oral intake can produce burning of the mouth, vomiting, diarrhea, and abdominal cramps. Skin contact can cause rashes. 

Nitrosyl chloride is a toxic gas and a severe irritant to eyes, skin, and mucous membranes. Inhalation can result in pulmonary edema and hemorrhage. 

The compound is highly irritating to skin, eyes and mucous membranes. Inhaling its vapors can cause pulmonary edema. 

CAUTION Trifluoroacetic acid is corrosive and severely irritating to skin, eyes, and mucous membranes. Inhalation can destroy tissue and be fatal. Appropriate safety precautions and procedures should be adopted when handling this reagent. 

Membranes Inhalation anaesthetics (diethylether, chloroform, and their more modem replacements). The mode of action of these was enshrouded in mystery for a long time, but accumulating evidence now supports direct interaction with several ion channels. Nevertheless, there is a remarkably close correlation between the ability of these agents to partition into lipid membranes, as measured by their oil-water partition coefficients, and their narcotic activity so, in a sense, cell membranes may be considered the targets of these agents. 

SAFETY PROFILE Poison by inhalation and ingestion. A corrosive irritant to skin, eyes, and mucous membranes. Inhalation may cause pulmonary edema and hemorrhage. Potentially explosive reaction with acetone + platinum. Mixtures with hydrogen + oxygen ignite spontaneously. When heated to decomposition it emits very toxic fumes of CT and NO. ... 

Triethanolamine may be irritant to the skin, eyes, and mucous membranes. Inhalation of vapor may be harmful. Protective clothing, gloves, eye protection, and a respirator are recommended. Ideally, triethanolamine should be handled in a fume cupboard. On heating, triethanolamine forms highly toxic nitrous fumes. Triethanolamine is combustible. 

The acute oral toxicity of Folpet for rats was not reached at 10 g/kg, for mice it was 2440 mg/kg. It does cause skin irritation in rabbits the acute dermal toxicity for rabbits was not reached at 5 g/kg according to one source, but according to another its dermal LC50 of 22.6 g/kg was reported for rabbits. Folpet is considered slightly toxic by ingestion. It is not considered as an eye irritant to rabbits. Acute inhalation exposure to Folpet may cause irritation of the mucous membranes. Inhalation of dust or spray mists and contact with the eyes can also result in local irritation. 

Human Toxicity Mildly irritating to skin, mucous membranes. Inhalation of high concns causes narcosis, unconsciousness. Death may occur due to respiratory paralysis, cf. Toxicity and Metabolism of Industrial Solvents, E, Browning, Ed. (Elsevier. New York, 1965) pp 493-498. 

Human Toxic in. Intensely irritating to eyes, skin, mucous membranes. Inhalation may cause pulmonary edema, hemorrhage. 

Toxicity Boron trifluoride (and organic complexes such as Bp3-etherate) are extremely corrosive substances that are destructive to all tissues of the body. Upon contact with moisture in the skin and other tissues, these compounds react to form hydrofluoric acid and fluoroboiic acid, which cause severe burns. Boron trifluoride gas is extremely irritating to the skin, eyes, and mucous membranes. Inhalation of boron trifluoride can cause severe irritation and burning of the respiratory tract, difficulty breathing, and possibly respiratory failure and death. Exposure of the eyes to BF3 can cause severe burns and blindness. This compound is not considered to have adequate warning properties. Boron trifluoride has not been found to be carcinogenic or to show reproductive or developmental toxicity in humans. Chronic exposure to boron trifluoride gas can cause respiratory irritation and damage. 

Toxicity Trimethylaluminum and related alkylaluminum reagents are pyrophoric materials that can react explosively with the moisture in tissues, causing severe bums. The heat of reaction can also ignite the methane gas generated, resulting in thermal bums. Alkylaluminum reagents are corrosive substances, and contact is extremely destractive to the eyes, skin, and mucous membranes. Inhalation of trimethylaluminum and other volatile alkylaluminum compounds may cause severe damage to the respiratory tract and can lead to fatal pulmonary edema. 

Vibrating) membrane inhalers with a high output rate based on different aerosol generation principles, designs and performances... 

Jet nebulisers in the home situation are increasingly replaced by (vibrating) membrane inhalers which give better control over the medicine delivery to the respiratory tract than the classic jet and ultrasonic nebulisers, and may increase the adherence to the therapy. 

Many of these materials are acutely toxic upon inhalation and very corrosive to the skin, eyes, and mucous membranes. Inhalation may also result in insidious adverse effects such as delayed respiratory impairment. In other words, exposure to these materials could result in impairment many hours after inhalation which mandates that any persoimel that inhale these materials be evaluated by a qualified physician. 

Absorption. Because they are lipid-soiubie, the organochlorines are readily absorbed by the skin and mucous membranes. Inhalation does not pose a significant problem because the organochlorines are not highly volatile. 

---