Melt granulation processes

Evrard, B. Amighi, K. Beten, D. Delattre, L. Moes, A.J. Influence of melting and rheological properties of fatty binders on the melt granulation process in a high-shear mixer. Drug Dev. Ind. Pharm. 1999, 25 (11), 1177-1184. 

In TVA s production of UAP by a melt granulation process, mentioned previously, ammonium polyphosphate melt and molten urea were cogranulated in... 

A series of studies have been carried out by Schaefer and his colleagues to investigate the effects of formulation and process variables on the hot-melt granulation process, and the properties of the obtained granules (7-13). 

The hot-melt extrusion technology in some cases can be run as a continuous process, having a higher throughput than batch hot-melt granulation process per batches. 

McTaggart CM, Ganley JA, Sickmueller A, Walker SE. The evaluation of formulation and processing conditions of a melt granulation process. Int J Pharm 1984 19 139-148. 

Three steps are essential to ammonium nitrate manufacture neutralization of nitric acid with ammonia to produce a concentrated solution evaporation to give a melt and processing by prilling or granulation to give the commercial soHd product. 

Fig. 1 DSC thermogram of LDPE directly (flakes), after washing and melting (granulates) and processing (bags)...

The AZF pipe reactor process from La Grande Paroisse was combined with the fluidized dram granulator process from Kaltenbach-Thiiring S.A. The design melt concentration from the plant is 92% with 94% being achievable. The steam from the process is used to preheat the nitric acid feed and to vaporize the ammonia feed229. 

Granulation Process Urea Melt Concentration tweight% ) Product Temperature (°C) Steam (kg/ tonne 11 tea) Power (MJ/ tonne 1 Irea)... 

Hydrogenated Vegetable Oils These primarily consist of the family of stearines. Hydrogenated castor oil (Cutina HR ) has been used as a wax matrix material both in melt-granulation and spray-congealing processes.f ... 

The melt processes require at least a meltable material in the manufacture of the solid dosage form. This article intends to address the influence of meltable materials on the processes of melt pelletization, melt granulation, and tumbling melt granulation. Approaches to meet the processing attributes of the meltable materials for these melt agglomeration processes, via spray congealing, are discussed. 

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