Melanocortin-4 receptor gene

Yeo, G. S. H., Lank, E. J., Farooqi, I. S., Keogh, J., Challis, B. G., and O RahiUy, S. (2003) Mutations in the human melanocortin-4 receptor gene associated with severe famUial obesity disrupts receptor function through multiple molecular mechanisms. Hum. Mol. Genet. 12, 561-574. 

Branson R, Potoczna N, Krai JG et al (2003) Binge eating as a major phenotype of melanocortin 4 receptor gene mutations. N Engl J Med 348 1096-1103... 

Malhotra AK, Correll CU, Chowdhury NI, Muller DJ, Gregersen PK, Lee AT et al (2012) Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain. Arch Gen Psychiatty 69 904-912... 

Trevaskis JL, Butler AA (2005) Double leptin and melanocortin-4 receptor gene mutations have an additive effect on fat mass and are associated with reduced effects of leptin on weight loss and food intake. Endocrinology 146 4257-4265... 

Agouti Gene and Agouti Protein Melanocortin Receptors Proposed Feedback Loop Fat Gene and Carboxypeptidase E Tubby Gene Summary References Bibliography... 

Lee EJ, Lee SI I, Jung JW, et al. Differential regulation of cAMP-mediated gene transcription and ligand selectivity by MC3R and MC4R melanocortin receptors. Eur J Biochem 2001 268 582-591. 

Mogil JS, Wilson SG, Chesler EJ, et al. The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proc Natl Acad Sci U S A 2003 100(8) 4867-72. 

Mogil JS, Ritchie J, Smith SB, et al. Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans. J Med Genet 2005 42(7) 583-7. 

Mountjoy, K.G., Robbins, L.S., Mortrud, M.T. Cone, R.D. (1992) The cloning of a family of genes that encode the melanocortin receptors. Science 257, 1248-1251. 

The cloning of a family of genes that encode the melanocortin receptors. Science 257 1248-1251. 

Chagnon, Y. C. et al.. Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity related phenotypes in the Quebec Family Study, Mol. Med., 3, 663-673,1997. 

The Melanocortin-1 receptor (MCIR) gene variants offer additional interesting evidence of the potential for highly targeted analgesia based on sex and other differences. There is evidence that women, more than men,... 

Hanada R, Nakazato M. Matsukura S, Murakami N, Yoshimatsu H. Sakata T. Differential regulation of melanin-concentrating hormone and orexin genes in the agouti-related protein/melanocortin-4 receptor system. Biochem Biophys Res Commun 2000 268 88-91. 

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