Medical Research Council MRC

The Medical Research Council (MRC) dyspnea scale can be used to monitor physical limitation due to breathlessness... 

Brada M, Thomas DGT, Bleehan NM. Medical Research Council (MRC) randomized trial of adjuvant chemotherapy in high grade glioma (HGG). ProcAm Soc Clin Oncol 1998 17 400. 

Primary antibody specific for a linear HIV epitope, for example we use a mixture of two murine anti-HIV-1 p24 antigen MAbs, 38 96K and EF7 (46), which recognize the majority of primary and T-cell line adapted HIV-1 strains. These MAbs are available from EU Programme EVA Centralised Facility and the Medical Research Council (MRC) AIDS Reagent Project (repository reference numbers EVA365 and EVA366). 

Adolfo Saiardi, Medical Research Council (MRC) Cell Biology Unit and Laboratory for Molecular Cell Biology, Department of Biochemistry and Molecular Biology, University College London, London, United Kingdom... 

In the UK Medical Research Council (MRC) trial, the outcome of antihypertensive treatment based on diuretics was compared with placebo in a very large number of hypertensive subjects (11). Treatment based on a thiazide did not increase the incidence of coronary events or sudden death indeed, thiazide-based treatment reduced the incidence of strokes by 67% and of all cardiovascular complications by 20%. It should be noted that the dose of bendroflumethiazide used in the MRC trial (lOmg/day) is now known to be unnecessarily high and that it was used without prophylaxis against hypokalemia. Even so, a subgroup analysis of data from the MRC Trial provided no evidence that the association between major electrocardiographic abnormalities and an increased likelihood of a clinical event was strengthened by bendroflumethiazide treatment (12). 

MT-4 cells can be obtained from the Medical Research Council (MRC) or from the National Institutes of Health (NIH). 

Three landmark placebo-controlled clinical trials have established the benefits of both hypertension treatment and diuretic therapy. The Systolic Hypertension in the Elderly Program (SHEP), the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension), and the Medical Research Council (MRC) trial " showed significant reductions in stroke, myocardial infarction, and aU-cause cardiovascular disease and mortality with thiazide diuretic-based therapy versus placebo. These trials allowed for /3-blockers as add-on therapy for BP control. Newer agents (i.e., ACE inhibitors, angiotensin II receptor blockers [ARBs], and calcium channel blockers [CCBs]) were not available at the time of these studies. However, subsequent clinical trials have compared these newer antihypertensive agents (ACE inhibitors, ARBs, and CCBs) to diuretics." These data show similar effects, but most trials used a prospective, open-label, blinded end point (PROBE) study methodology that is... 

In 1973, Butcher, Mitchell and Cohen (with support from the United Kingdom Medical Research Council (MRC) and World Health Organization (WHO, Geneva, Switzerland)) used an in vitro short-term culture system to study invasion and found that red cells from Old World monkeys... 

The latter methods are now used in clinical practice, and the results are usually given quantitatively, in some cases in international units calibrated against the Medical Research Council (MRC) 65/93 Feldt-Rasmussen (1996). Several studies have found large differences in the performance of different assays for measuring Tg-Ab (Arai et aL, 2000 Feldt-Rasmussen, 1996 Lindberg et aL, 2001). 

Acknowledgments The author s work in the area of depression emd stress is supported by the South African Medical Research Council (MRC) and the National Research Foundation (grant number 2073038). 

We are grateful to our colleagues and collaborators who have helped develop these methodologies and provided reagents. This work was supported by the Medical Research Council (MRC), Wellcome Trust, and Fight for Sight. 

Although responsibility for chemical warfare research rested with different departments, British scientists did not follow this division of labour in practice instead, they established informal networks and channels of communication which allowed them to coordinate, as best they could, their work throughout the war, and advance their professional careers thereafter. Appreciating the potential limitations of being integrated into the military and ministerial hierarchy, scientists used some of the newly created departments and expert committees on chemical warfare for the exchange of information and avoidance of duplication, for example at the War Office, the Ministry of Munitions, the Royal Society, and the Medical Research Committee, the predecessor of the Medical Research Council (MRC), founded under Royal Charter in 1920. ... 

APL is characterized by the t( 15 17) yet, in a recent study of 100 patients entered into the UK Medical Research Council (MRC) ATRA trial for APL, conventional cytogenetics failed to identify this translocation in 13% patients in whom its molecular consequence, the PML-RARa rearrangement, was ultimately successfully found by reverse transcriptase-polymerase chain reaction (RT-PCR) (5) Inability to detect t(15 17) on karyotype assessment most com-... 

There is significant variability in the rate of progression in LAM. Ten years following the onset of symptoms, approximately 55% of patients with LAM have developed Medical Research Council (MRC) grade 3 dyspnea (shortness of breath walking on flat ground), 23% require supplemental oxygen, and 10% are housebound (83). 

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