Measurement of growth hormone

Popii V, Baumann G. Laboratory measurement of growth hormone. Clin Chim Acta 2004 350 1-16... 

The dose level of -agonists affects the response obtained, the optimum dose often varies for the different production parameters measured. The mode of action of -agonists is poorly understood, but their interaction with membrane-bound receptors increases lipolysis in adipose cells and stimulates hypertrophy in muscle fibers. Although -agonists are known to stimulate the secretion of growth hormone and insulin, there is no direct evidence that these hormones mediate the tissue responses to the drug. 

Barunann G. Growth hormone binding proteins and various forms of growth hormone implications for measurements. Acta Paediatr Scand SuppI 1990 370 72-80. 

L2. Laron, Z., Pertzelan, A., Karp, M., Kowadlo-Silbergeld, A., and Daughaday, W. H., Administration of growth hormone to patients with familial dwarfism with hi plasma immunoreactive growth hormone Measurement of sulfiition facfair, metaboUc and linear growth responses. /. Clin. Endocrinol. Metab. 33, 332-342 (1971). 

Levitsky LL, Schoeller DA, Lambert GH, Edidin DV (1989) Effect of growth hormone therapy in growth hormone-deficient children on cytochrome P-450-dependent 3-V-demethylation of caffeine as measured by the caffeine C02 breath test. Dev Pharmacol Ther 12 90-95... 

The development of radioimmunoassays has permitted measurement of the amount of growth hormone in the blood of acromegalics. The normal blood level may be increased up to 100 times in acromegalics. Patients who develop no further symptoms of acromegaly continue to have excessive amounts of growth hormone in their blood. 

Hart, G. R. Ray, K. P. Wallis, M. Use of quin 2 to measure calcium concentrations in ovine anterior pituitary cells and the effects of quin 2 on secretion of growth hormone and prolactin. FEBS Lett. 1986, 203, 77-81. 

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