Growth hormone binding protein

Fisker S, Ebdmp L, Orskov H Influence of growth hormone binding protein on growth hormone estimation in different immunoassays. Scand.J. Clin. Lab. Invest. 

Fig. 7. Three different binding sites used by the immunoglobulin-like proteins tbe PapD chaperone, the antigen-binding fragment of an immunoglobulin (Fab ), and the human growth hormone-binding protein (hCHbp). Each immunoglobulin-like domain is...

Barunann G. Growth hormone binding proteins and various forms of growth hormone implications for measurements. Acta Paediatr Scand SuppI 1990 370 72-80. 

Baumann, G., Shaw, M.A., and Buchanan, T.A. (1988) In vivo kinetics of a covalent growth hormone binding protein complex. Metabolism, 38, 330 333. 

Baumann G, Shaw M A, Amburn K (1994). Circulating growth hormone binding proteins./. Endocrinol. Invest. 17 67-81. 

Baumann G, Amburn K D, Buchanan T A (1987). The effect of circulating growth hormone-binding protein on metabolic clearance, distribution, and degradation of human growth hormone. /. Clin. Endocrinol. Metab. 64 657-660. 

Baumann G, Shaw M A, Brumbaugh R C, et al. (1991). Short stature and decreased serum growth hormone-binding protein in the Mountain Ok people of Papua New Guinea. J. Clin. Endocrinol. Metab. 72 1346-1349. 

Fig. 4 CH/jt interactions observed in human growth hormone-binding protein (PDB code 3HHR) Lys2l5/Tyr222/Arg213/Phe225/ Arg211/Trpl86/Lysl79 (From Ref [68J, Fig 10.)...

An example is given in Fig. 4 for a sequence of CH/ti bonds observed in human growth hormone-binding protein. Notice that the methylene hydrogens in Lys and Arg arc involved in a stacked manner with aromatic residues, Phe, Tyr, and Trp. 

Gro 1C-/actor signaling. Human growth hormone binds to a cell-surface membrane protein that is not a receptor tyrosine kinase. The intracellular domain of the receptor can bind other proteins inside the cell. Furthermore, studies indicate that the receptor is monomeric in the absence of hormone but dimerizes on hormone binding. Propose a possible mechanism for growth-hormone signaling. 

---