MDR1 mRNA levels

Nakamura, T., Sakaeda, T., Ohmoto, N., Tamura, T., Aoyama, N. et al., Real-time quantitative polymerase chain reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA levels in Caco-2 cell lines, human duodenal enterocytes, normal colorectal tissues, and colorectal adenocarcinomas, Drug Metab. Dispos. 2002, 30, 4—6. 

The expression level of intestinal MDR1 mRNA has been utilized to the personalized immunosuppressant therapy with tacrolimus in cases of living-donor liver transplantation (LDLT) [84], Tacrolimus shows wide... 

MDR1 (ABCB1 )IP-f>p. Pew studies addressed the induction of rat Mdrl genes on the mRNA level, only where the two rodent orthologs of human MDR1 can be differentiated. Rats, which were treated with PCN, spironolactone, ordexamethasone, did not show any induction of Mdrl a or Mdrl b in liver or intestine. In contrast, DAS... 

Moriya Y, Nakamura T, Horinouchi M, Sakaeda T, Tamura T, Aoyama N, Shirakawa T, Gotoh A, Fujimoto S, Matsuo M, Kasuga M, Okumura K. Effects of polymorphisms of MDR1, MRP1, and MRP2 genes on their mRNA expression levels in duodenal enterocytes of healthy Japanese. Biol Pharm Bull 2002 25 1356-1359. 

In breast cancer cells ZR-75-1 and T-47D, which also express only low levels of endogenous PXR, treatment with rifampin transiently induces the expression of SLCO1A2 mRNA in a dose- and time-dependent manner [114], Induction by rifampin was shown to be independent of de novo protein biosynthesis. In contrast to SLC01A2, MDR1 was not induced [114], The physiological relevance of these findings has to await further clarification. 

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