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Maximum tolerated dose programs

Farber, T.M. (1987). Pesticide assessment guidelines, subdivision F, position document Selection of a maximum tolerated dose (MTD) in oncogenicity studies. Toxicology Branch, Hazard Evaluation Division, Office of Pesticides Programs, USEPA. NTIS PB88-116736. [Pg.396]

There are several solutions to this problem. One of these has been the rather simplistic approach of the INUP Bioassay Program, which is to conduct a 3 month range-finding study with sufficient dose levels to establish a level that significantly (10%) decreases the rate of body weight gain. This dose is defined as the maximum tolerated dose (MTD) and is... [Pg.2639]

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See also in sourсe #XX -- [ Pg.134 ]



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Tolerance dose

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