Maturation promoting factor

Fulka, J., Jr., Jung, T., and Moor, R. M. (1992). The fall of biological maturation promoting factor (MPF) and histone HI kinase activity during anaphase and telophase in mouse oocytes. Mol. Reprod. Devel. 32 378-382. 

Gautier, J., Norbury, C., Lohka, M., Nurse, P., and Mailer, J. (1988). Purified maturation-promoting factor contains the product of a Xenopus homologue of the fission yeast cell cycle control gene cdc2+. Cell 54 433-439. 

Hashimoto, N., and Kishimoto, T. (1988). Regulation of meiotic metaphase by a cytoplasmic maturation-promoting factor during mouse oocyte maturation. Dev. Biol. 126 242-252. 

Lohka, M. J., Hayes, M. K., and Mailer, J. (1988). Purification of maturation-promoting factor, an intrinsic regulator of early mitotic events. Proc. Natl. Acad. Sci. USA 85 3009-3013. 

Murray, A. W., Solomon, M. J., and Kirschner, M. W. (1989). The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature 339 280-286. 

Sorenson, R. A., Cyert, M. S., and Pedersen, R. A. (1985). Active maturation-promoting factor is present in mature mouse oocytes. J. Cell Biol. 100 1637-1640. 

Wasserman, W. J., Richter, J. D., and Smith, L. D. (1982). Protein synthesis during maturation promoting factor- and progesterone-induced maturation in Xenopus oocytes. Dev. Biol. 89 152-158. 

Lohka MJ, Hayes MK, Mailer JL 1988 Purification of maturation-promoting factor, an intracellular regulator of early mitotic events. Proc Natl Acad Sci USA 85 3009—3013 Mailer JL, Butcher FR, Krebs EG 1979 Early effects of progesterone on levels of cyclic adenosine 3 5 -monophosphate in Xenopus oocytes. J Biol Chem 254 579-582 Masui Y 1967 Relative roles of the pituitary, follicle cells, and progesterone in the induction of oocyte maturation in Ranapipiens. J Exp Zool 166 365-375 Masui Y, Markert CL 1971 Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes. J Exp Zool 177 129-145... 

Holloway SL, Glotzer M, King RW, Murray AW 1993 Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor. Cell 73 1393-1402... 

Unfortunately, this field is made difficult for a student by the terminology used by biochemists. For example, there is a protein kinase that regulates the cycle between G2 and M, i.e. the second restriction point. This protein is known as maturation (or mitosis) promoting factor, since it promotes entry into mitosis. It phosphorylates a protein, probably a transcription factor, in the nucleus. The kinase has a molecular mass of 34kDa. Hence it is known as p34 cell division kinase, abbreviated to p34-cdc and, since it is regulated at restriction point 2, it is known as p34-cdc-2 protein, which is sometimes written as p34°. This kinase is normally inactive until it binds a cyclin. Hence the active maturation-promoting factor is, in fact, a protein kinase-cyclin complex, which is referred to as p34° °-cyclin complex. It is hoped that this piece of information may help a student (or lecturer from another field) to understand one part of a review article that contains the abbreviation p34° -cyclin complex, without explanation, or other similar pieces of biochemical shorthand. 

Cyclin B/CDKl is the primary regulator of the G2/M transition, and its activity is required for entry into mitosis. It was termed the maturation-promoting factor (MPF) because it was originally shown to be essential for Xenopus oocytes maturation... 

Osgood demonstrated that pernicious anemia serum delays maturation of megaloblastic bone marrow (see LI). The work of Callender and Lajtha (see G20) points out that addition of normal gastric juice potentiates the effect of vitamin B12 in counteracting this maturation-delaying effect of pernicious anemia serum. A B12 binder separated from normal gastric juice by electrophoresis or ammonium sulfate precipitation was also shown to enhance the B12 effect on maturation of the erythro-blasts, when added to bone marrow (P2, P3). The relation of this maturation-promoting factor to Castle s intrinsic factor is not clearly defined (see G20). 

Maturation-Promoting Factor (MPF) Stimulates Meiotic Maturation of Oocytes and Mitosis in Somatic Cells... 

Y. Masui. 2001. From oocyte maturation to the in vitro cell cycle the history of discoveries of Maturation-Promoting Factor (MPF) and Cytostatic Factor (CSF). Differentiation 69 1-17. 

Gautier, J., J. Minshull, M. Lohka, M. Glotzer, T. Hunt J.L. Mailer. 1990. Cyclin is a component of maturation-promoting factor from Xenopus. Cell 60 487-94. 

Molecular properties, and selforganization, 491,492 Morphogenesis, models for, 14,513 MPF, see Maturation-promoting factor Multiple instability mechanisms, 118,119, 279... 

Balamurugan K, Haider S. 1998. Partial purification of maturation-promoting factor from catfish, Claiias batrachus identification as the histone HI kinase and its periodic activation. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 120(3) 329-342. 

Choi T, Rulong S, Resau J, Fukasawa K, Matten W, Kuriyama R, Mansour S, Ahn N, Vande Woude GF. 1996. Mos/mitogen-activated protein kinase can induce early meiotic phenotypes in the absence of maturation-promoting factor a novel system for analyzing spindle formation during meiosis I. Proc Natl Acad Sci U S A 93(10) 4730-4735. 

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