Matrix-assisted laser desorption/ionization lateral resolution

Dissociation and ionization by means of one or several lasers. Sensitive detection of fragments and ions with resonance photoionization and mass spectrometric techniques (tunable lasers). Matrix-assisted laser desorption/ionization mass spectrometry (MALDI) with pulsed ablating laser sources. High lateral resolution enables molecular microprobing of biological cell compounds... [Pg.2456]

Traditional mass spectrometric imaging (MSI) methods, such as matrix-assisted laser desorption ionization (MALDI) and secondary ion mass spectrometry (SIMS), have become important tools for the investigation of molecular distributions in tissues due to their high ionization efficiencies and excellent lateral and depth resolutions. Invasive sample preparation and the need for vacuum conditions, however, are incompatible with the analysis of live samples. [Pg.159]