Materials with Boronate Avidity

4 Boronate Affinity-Based Molecularly Imprinted Polymers 

Molecularly imprinted polymers (MIPs) are synthetic materials that are able to specifically recognize target molecules or to catalyze specific reactions. The molecular imprinting technology has found important applications, 

The covalent imprinting of macromolecule such as glycoproteins using boronic acids as functional monomers appeared as early as 1985. Mos-bach and co-workers reported covalent imprinting of glycoproteins in 

The imprinted template in the MIP can be easily removed with an acidic solution, leaving cavities complementary to the 3D shape of the template. The approach is fast (total processing time less than 3 h) and has potential for easy mass production. More interestingly, the prepared MIP array exhibited several favorable features such as high specificity, superb tolerance for interference and the applicability to a wide range of sample pH values. 

Polv(AP0A-co- lo mine) OFF Boronato affiiWtv inaccivated 

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Although the first report on boronic acids was published in 1862, boronate affinity materials have not been extensively investigated until recently. In recent years, various boronate-functionalized materials, " such as macroporous monoliths, " " nanoparticles, and mesoporous materials, have been developed into important tools for the facile selective extraction of cis-diol-containing compounds. With these matrices, several important materials with teamed boronate affinity and boronate avidity as well as boronate affinity-based molecularly imprinted polymers have been prepared. 

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