Maslinic acids

Maslinic acid FruitpeeP LfOE030 Neoxanthene Fr fixed oiP ° ... 

Chamaenerion angustifolium (L.) Scop. C. angustifolium (L.) Scop. f. pubescens (Hausskn.) Kitag. Liu Lan (whole plant) Crataegolic acid, penta-o-galloyl-(i-d-gl Licose, maslinic acid, chanerol, cerylalcohol.48 Regulate menstruation, improve breast milk production. Externally for wounds, stop bleeding. 

Punica granatum L. Shi Liu Pi (Pomegranate) (pericarp, root bark) Pelletierine, isopelletierine, methylisopelletierine, methyl-pelletierine, pseudopelletierine, gallotannic acid, sitosterol, ursolic acid, maslinic acid, elegic and gallic acid.33-450 This herb is toxic. Purges intestinal parasites. 

Maslinic acid Chamaenerion angustifolium, Crataegus cuneata, C. chlorusarca, C. dahurica, C. maximowiczii, C. pentagyna, C. pinnatifida, C. sanguinea, Punica granatam,... 

Licania heteromorpha var. heteromorpha Bentham is a tree up to 30 m high native to the Amazonian forest. Phytochemical study of its aerial parts yielded both triterpenes and flavonoids triterpenes were obtained from the chloroform extract by silica gel column followed by RP-HPLC and were characterised as betulinic acid (11), alphitolic acid (48), 3(3-0-trans-p-coumaroyl alphitolic acid (49), 3(3-0-cw-p-coumaroyl alphitolic acid (50), 3 -0-trans-p-coumaroyl maslinic acid (51), 3fi-O-cis-p-coumaroyl maslinic acid (52), 3(3-0-tnms,-/ -coumaroyl-2a-hydroxy-urs-12-en-28-oic acid (53), 3 3-0-m-p-coumaroyl-2a-hydroxy-urs-12-en-28-oic acid (54) [see Fig. (2) and (6)] [15], Compounds 11 and 48-54 were identified comparing their H and 13C NMR data with those previously described. Triterpenoids 48-54 were found for the first time in Licania, while betulinic acid had been isolated previously from L. carii [9]. On the other hand, flavonoids were isolated from the chloroform-methanol and methanol residues by Sephadex LH-20 and HPLC they were identified as myricetin 3-0- 3-D-galactopyranoside (17), myricetin 3-0-a-L-rhamnopyranoside (32), myricetin 4 -methylether-3-0- 3-D-glucopyranoside (55), myricetin 4 -methylether-3-0-a-L-rhamnopyranoside (45), myricetin 3,4 -di-0-a-L-rhamnopyranoside (56), myricetin 7-methylether 3,4 -di-0-a-L-rhamnopyranoside (57), and myricetin 4 -methylether-3-0- 3-D-galactopyranoside (58) [see Fig. (2), (4), and (6)]. The last three myricetin derivatives were new natural compounds [16]. Known compounds were identified by comparison of their H and l3C NMR spectra with those reported in the literature [15]. 

Maslinic acid Geum japonica (Rosaceae) HIV-1 protease (100% [49,... 

Cloves contain about 2% of the triterpene, oleanolic acid. Narayanan and Natu (1974) isolated maslinic acid from clove buds. From clove, 2a-hydroxyoleanolic acid was isolated by Brieskorn et al. (1975). 

Triterpenic Acids. The following pentacyclic mono- and dihydroxy triterpenic acids are present in virgin olive oil (35, 43, 44) 3p-hydroxy-17-carboxy-5-12-olea-nene (oleanolic acid) 3 3,2a-dihydroxy-17-carboxy-5-12-oleanene (maslinic acid) 3p-hydroxy-17-carboxy-8-12-ursene (ursolic acid) 2a,3p-dihydroxy-17-carboxy-5-12-ursene (2a-hydroxyursolic acid) and deoxyursolic acid (structure not fully elucidated). 

Studies of the CHCI3 extract of E.japonica resulted in the isolation of a new derivative 3p, 6a, 19a trihydroxy-urs-12-en-28-oic acid, 5, besides the already reported maslinic acid 6, 2a-hydroxy-ursolic acid 7, 2a, 3a, 19a-trihydroxy-urs-12-en-28 oic acid or tormentic acid 8, 2a, 3p,19a, 23-tetrahydroxy-urs-12-en-28-oic acid 9 and ursolic acid 10 ( Fig.l). 

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