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Marine source drugs

The discovery of a new drug is part luck and part structured investigation (see section 3.1). It originally started with drugs and lead compounds derived from natural sources, such as animals, plants, trees and microorganisms. Marine sources were not utilized to any extent until the mid-20th century. Today, natural sources are still important, but the majority of lead compounds are synthesized in the laboratory. The nature of these synthetic compounds is initially decided from a consideration of the biochemistry of the pathogenic condition. [Pg.43]

Exploration of the molecular basis of human disease will continue to provide additional targets for drug discovery, while a better understanding of marine ecological interactions at the molecular level can be used to guide the selection of novel sources and novel screens. This multidisciplinary approach to discovery of marine-derived drugs will likely result in the continued discovery of unique bioactive chemical entities and new ways to address the treatment of human disease. [Pg.537]

Currently, no approved antitumor drugs directly are derived from marine sources, but ecteinascidin (Yondelis PharmaMar, Madrid, Spain) was submitted to the EMEA in early August... [Pg.1149]

Many of the naturally occurring tricyclic thiazines are essentially naphtho analogues of the benzothiazines discussed in the previous section, and are isolated mainly from bacterial or marine sources, although the best-known tricyclic thiazine is the phenothiazine chlorpromazine. This compound, 2-chloro-l 0-(3-dimethylaminopropyl)phenothiazine developed in the early 1950s was one of the first antipsychotic drugs on the market, and although it is claimed to be a natural product (03MI05), the evidence is extremely weak, and therefore it is not included here. [Pg.62]

Diterpenes from marine sources, insecticidal properties of, 243-244 Ditriiolhreitol, 112 DNA, sec Deoxyribonucleic acid Dopamine, lobeline-induced release of, 154 Dose—response relationship. 2 Drug discovery, see also Manufacturing process ICBC program in Suriname... [Pg.268]

X. Lin, M. Liu, C. Hu, and D. Liao, Targeting cellular proapoptotic molecules for developing anticancer agents from marine sources. Curr. Drug Targets, 11 (2010) 708-15. [Pg.33]

Younes, I., Rinaudo, M., 2015. Chitin and chitosan preparation from marine sources, structure, properties and apphcations. Marine Drugs 13, 1133—1174. [Pg.35]

Nuijen, B., Bouma, M., Manada, C., Jimeno, J.M., Schellens, J.H.M., Bult, A., and Beijnen, J.H. (2000) Pharmaceutical development of anticancer agents derived from marine sources. Anti-Cancer Drugs, 11,793-811. [Pg.55]

Fahmy, H., Zjawiony, J.K., Konoshima, T, Tokuda, H Khan, S and Khalifa, S. (2006) Potent skin cancer chemopreventing activity of some novel semi-synthetic cembranoids from marine sources. Mar. Drugs, 4, 28-36. [Pg.1375]


See other pages where Marine source drugs is mentioned: [Pg.62]    [Pg.295]    [Pg.10]    [Pg.70]    [Pg.237]    [Pg.333]    [Pg.12]    [Pg.62]    [Pg.482]    [Pg.683]    [Pg.44]    [Pg.531]    [Pg.13]    [Pg.646]    [Pg.2559]    [Pg.101]    [Pg.757]    [Pg.119]    [Pg.175]    [Pg.427]    [Pg.646]    [Pg.108]    [Pg.141]    [Pg.103]    [Pg.352]    [Pg.354]    [Pg.89]    [Pg.112]    [Pg.35]    [Pg.175]    [Pg.296]    [Pg.456]    [Pg.60]    [Pg.145]    [Pg.70]    [Pg.268]    [Pg.458]    [Pg.68]   


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