Margin ratio, definition

The standard safety margin has definitive advantages over therapeutic ratio. In contrast to the LD50/ED50 index, the standard safety margin is influenced not only by the distance between central points of the anesthetic... 

The Margin of Exposure (MOE) in the context of the assessment of compounds that are both genotoxic and carcinogenic, as defined in EFSA (2005), is different from the OECD/IPCS definition given above The Margin of Exposure (MOE) is the ratio between a defined point on the dose-response curve (reference point) for the adverse effect of the compound in the animal carcinogenicity study and the estimated human intake of the compound. ... 

One of the attractions of flame atomic absorption is that relative standard deviations are often better then 1% in ideal situations and only marginally poorer than this when lower levels are being analysed. By definition the precision of measurement is 50% relative standard deviation at the detection limit, because it is at this point that the signal to noise ratio equals 2. 

The conditions governing miscibility in the solid state are fairly well understood. The atoms and molecules which enter into the mixed lattice must not differ by more than a limited margin in size. Furthermore, the detailed study of alloys has revealed that the possible solid phases are determined by certain definite electron ratios, and that in fact the structure is mainly governed by the concentration of valency electrons. 

Patients with osteoarthritis or rheumatoid arthritis are randomized to one of three treatments, celecoxib, ibuprofen, or naproxen, and the primary endpoint is the occurrence of a cardiovascular endpoint a nonfatal myocardial infarction, a nonfatal stroke, or any cardiovascular death. Non-inferiority will be assessed for three different pairwise comparisons celecoxib versus ibuprofen, celecoxib versus naproxen, and ibuprofen versus naproxen. The definition of non-inferiority differs somewhat from the fixed margin approach describe earlier in that there are separate criteria for the confidence interval and the point estimate. The hazard ratio for each comparison will be calculated, and non-inferiority will be concluded if the upper end of the... 

The following numerical value was found by Billet [5], Chap. 2, for the vapour capacity factor Fypi with L/V = fo]. same system and a marginally different phase flow ratio, compared to the one specified in the task definition ... 

---