Manufacturing transdermal delivery systems

CONCLUSIONS The process for manufacturing transdermal delivery systems has been... 

Approved packaging is normally selected after completing package performance qualification testing as well as product compatibility and stability studies. Since in most cases (exceptions transdermal delivery systems, diagnostic tests, and medical devices) packaging is not intimately involved in the manufacturing process of the product itself, it differs from other factors, such as raw materials. 

OBJECTIVE To validate the manufacturing process for transdermal delivery systems by... 

Peterson, T., Wick, S., and Ko, C. Design, development, manufacturing, and testing of transdermal dru delivery systems, in Ghosh, T., Pfister, W., and Yum, S. (eds.), Transdermal and Topical Drug Delivery Systems. Buffalo Grove, IL Interpharm Press, 1997, pp. 249-298. 

Formulation and/or development of advanced drug-delivery systems such as microencapsulated molecules, transdermal patches, or liposomes are frequently accomplished in the laboratory. However, large-scale production of these dosage forms may be problematic because the same conditions of manufacture may not be attainable or desirable in the plant setting. Consultation with process development personnel during the finalization of the prototype development phase is one way of minimizing scale-up difficulties. 

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