Malaria boxes

Similar screening exercises from other compound collections have successfully revealed additional target classes,53 though in these studies the more difficult path of in vitro testing combined with the absence of a broad kinase screen for the Plasmodium kinome means that this class of targets is 

Marsden and S. Knapp, Curr. Opin. Chem. Biol, 2008, 12, 40-45. 

Eswaran and S. Knapp, Biochim. Biophys. Acta, 1804, 429M-32. 

Tewari, U. Straschil, A. Bateman, U. Bohme, I. Cherevach, P. Gong, A. Pain and O. Billker, Cell Host Microbe, 8, 377-387. 

Reininger, R. Tewari, C. Fennell, Z. Holland, D. Goldring, L. Ranford-Cartwright, O. Billker and C. Doerig, J. Biol. Chem., 2009, 284, 20858-20868. 

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At present, there are two streams of drug discovery activity that could lead to the successful development of a kinase inhibitor as a drug for Plasmodium Malaria, namely in vitro screening activities around validated kinase targets and deconvolution of key targets revealed from the screening of various Malaria Boxes on various stages of the life cycle of the parasite. 

Kowalczyk, P., McDonald, S., Wells, T.N. C., and Willis, P. (2013) The open access malaria box a drug discovery catalyst for neglected diseases. PLoS ONE, 8, e62906. 

Resistance is now common in several organisms, for example Yersinia pestis and Vibrio cholerae. In addition, the parasite that causes malaria (Plasmodium) is resistant to most drugs (Box 17.8). 

Major causes of morbidity and mortality in many developing countries such as malaria, tuberculosis, pneumonia, acute diarrheas, maternal diseases can be treated with simple essential medicines (Box 1). But, essential medicines will save lives and improve health, only if they are available, affordable and of good quality, and properly utilized. 

BOX 7-B SICKLE CELL DISEASE, MALARIA, AND BLOOD SUBSTITUTES... 

Microscopic binding constants and statistical effects 360 Box 7-B Sickle Cell Disease, Malaria, and... 

The common box wood, Buxas sempervirens, has long been known for its medicinal properties extracts of the plant (23) were used against various kinds of diseases such as malaria and venereal diseases. The extract was reported to possess an antitubercular property. Steroidal amines were isolated from the plant and their structures, including cyclobuxine D and cyclomicophylline A were clarified (19,20). 

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