Major sperm protein

The present volume covers Muscle and Molecular Motors . The first few chapters describe the ultrastructures of striated muscles and of various muscle filaments (myosin, actin, titin), they discuss the regulation of muscle contractile activity, and they explore the mechanism of force production and movement. The book then sets out to survey other kinds of motor systems microtubules and their interactions with both microtubule associated proteins (MAPs) and the motor proteins kinesin and dynein, the major sperm protein in nematodes, the rotary ATPases driven by or driving proton gradients, and the action of motor enzymes, polymerases, on nucleic acids. The aim throughout is to explore different molecular mechanisms of motor action in order to identify common themes. 

Italiano, J. E., Jr., Stewart, M., and Roberts, T. M. (1999). Localized depolymerization of the major sperm protein cytoskeleton correlates with the forward movement of the cell body in the amoeboid movement of nematode sperm. J. Cell Biol. 146, 1087-1095. 

King, K. L., Stewart, M., Roberts, T. M., and Seavy, M. (1992). Structure and macromo-lecular assembly of two isoforms of the major sperm protein (MSP) from the amoeboid sperm of the nematode, Ascaris suum..J. Cell Sci. 101, 847-857. 

Roberts, T. M., Salmon, E. D., and Stewart, M. (1998). Hydrostatic pressure shows that lamellipodial motility in Ascaris sperm requires membrane-associated major sperm protein filament nucleation and elongation./. Cell Biol. 140, 367-375. 

Scott, A. L., Dinman, J., Sussman, D. J. and Ward, S. (1988) Major sperm protein and actin genes in free-living and parasitic nematodes. Parasitology 98 471-478. 

The q toskeleton of eukaryotic cells is generally considered to be a meshwork of protein filaments that spans the space between the nucleus and the plasma membrane. In many cell types, the three-dimensional (3D) composite network of actin filaments, microtubules (MTs), and intermediate filaments (IPs) in the cytoplasm interfaces with two-dimensional networks composed largely of spectrins that line the plasma membrane and nuclear lamins that line the inner surface of the nuclear membrane. A few eukaryotic cell types contain an entirely different cytoskeleton that powers their locomotion and which is constmcted from the cationic major sperm protein instead of actin. The three cytoskeletal proteins, acdn, tubulin, and IF subunits, constitute a significant fraction of... 

Italiano, J.E., Jr., M. Stewart, and T.M. Roberts, How the assembly dynamics of the nematode major sperm protein generate amoeboid cell motility. Int. Rev. CytoL, 2001, 202 1-34. 

MSP (major sperm protein), in cell motality, 62-9 MTBI (mild traumatic brain injury), 52-4 Mullins, ., 54-16 Multi-functional 22-channel functional electrical stimulator development, for paraplegia,... 

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