Magistral preparations

The use of extemporaneous preparation should be limited to situations where there is no product with marketing authorization (MA) available. This could be prepared based upon a prescription for a named patient (magistral preparation) or a production based upon a formula and prepared on a regular basis. The latter is a... 

Independent of which regulation applies at a national level to extemporaneous or magistral preparation of radiopharmaceuticals, the patients should be entitled to expect that these products are prepared accurately, are suitable for use, and will meet the expected standards for quality assurance. Pharmacists involved in this kind of production must ensure that they and any other staff involved are competent to undertake the tasks to be performed and that the requisite facilities and equipment are available [11], As for other radiopharmaceutical production, systems must be in place to ensure the operator safety due to handling of radioactive materials. All involved staff must have sufficient training in radiation safety issues, in addition to training in GMP. 

In the patio process the finely ground ore is mixed in a patio or paved courtyard with mercury, common salt, and a mixture of copper and iron sulphates called magistral, prepared by roasting copper pyrites. The ore-heap or torta is kept moist. The reactions involved are obscure and complex, but it is supposed 1 that some of them can be represented thus ... 

Petit, P. Vers un renouveau des preparations magistrates grace a la formation continue, le pharmacien de france no. 12 (June, 1974), p. 569, through. Rev. d Hist. Pharm. 1975, 63 (227). 

The prices of magistral formulae and pharmacy-made preparations are recorded in the Medicinal Products and Preparations General Prices Scheme, which is reviewed annually by INFARMED after hearing the opinions of the Department of Competition and Prices, the College of Pharmacists and the pheirmacies representative bodies. The prices are approved by a despacho from the Minister of Health. 

The majority of the witnesses were English and native physicians, civil and medical officials, magistrates and policemen, farmers, traders, and missionaries. The evidence which they gave consisted of their answers to carefully worded questions prepared by the commission. 

Any medicinal product prepared in a pharmacy in accordance with a medical prescription for an individual patient (commonly known as the magistral formula). 

Ideally, extemporaneous products are prepared from pure drugs (or less suitably from chemicals) but, more frequently, commercial dosage forms intended for adults are manipulated into a suitable form for administration to children. They should be prepared in registered premises (pharmacy, hospital, health centre) under the supervision of a pharmacist and in accordance with a prescription for administration to a particular patient or in anticipation of such a prescription. These manipulations come under the heading of magistral (extemporaneous) preparations. Specials have a similar status but are made in larger volumes by licensed manufacturers (licence issued by the MHRA in the UK), which include suitably licensed hospital units. However, these products are not always subjected to full quality assurance. 

Formai notification to the authorities of an injury suffered by a party consisted in the compiaint being recorded in pubiic acts acta), a mandatory step in preparation for judiciai action by magistrates. 

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