Macrophages transcription factors

In order to investigate whether EPS was able to activate the macrophage transcription factor NFkB, which after translocation to the nucleus controls the transcription of several genes, mouse peritoneal macrophages were cultivated with two different EPS preparations (1 pg/ml) and EPS for comparison. The activation of NFkB was measured by an electromobility shift assay (Fig. 3). 

Roy S, Cain KJ, Chapin RB, Charboneau RG, Barke RA (1998) Morphine modulates NF kappa B activation in macrophages. Biochem Biophys Res Commun 245 392-396 Roy S, Wang J, Gupta S, Charboneau R, Loh HH, Barke RA (2004) Chronic morphine treatment differentiates T helper cells to Th2 effector cells by modulating transcription factors GATA 3 and T-bet. J Neuroimmunol 147 78-81... 

RAJAVASHISTH T B, YAMADA H and MiSHRA N K (1995) Transcriptional activation of macrophage stimulating factor gene by minimally modified LDL Arteriosclerosis, Thrombosis and Vascular Biology 15, 1591-8. 

A growing body of evidence links demethylase dysfunction to other disease areas. JMJD3 expression is induced in macrophages by the inflammatory transcription factor NF/vB in response to microbial stimuli,... 

PUT PUT transcription factor Osteopetrosis without osteoclasts Macrophage deficiency... 

Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Katoh Y, Bannai S, Yamamoto M. 2000. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem 275 16023-16029. 

Recent studies revealed that resveratrol protects from inflammation by acting at different phases of inflammation. Protection at the pro-inflammatory phase appears to be very important for reducing inflammation effectively and promptly. A recent study [Ge et al., 2006] showed that resveratrol inhibits macrophage expression of EMMPRIN by activating PPAR-y. In another similar study, Ma et al., [2006] showed a similar observation, but additionally found a role of nuclear transcription factor kB (NF-kB) in macrophage inhibition. Numerous studies confirmed that resveratrol suppresses the TNF-a... 

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