Macrophages antigenic determinants

Todd RF, III, Schlossman SF. Analysis of antigenic determinants on human monocytes and macrophages. Blood 1982 59(4) 775-786. 

Interactions of macrophages bearing cytophilic antibodies (armed macrophages) with target cells bearing antigenic determinants. 

The cellular basis of the immune response consists essentially in a phenomenon of multiplication and differentiation of T and B lymphoc34 es stimulated by the antigen processed in macrophages. The selection of the specific clone of lymphocytes is made by the stereospecific combination of antigen determinants with pre-existing receptors on the lymphocyte surface. In B lymphocytes, these receptors are immunoglobulins the nature of the receptors in T lymphocytes is still controversial. 

The activation of a T-cell response and subsequent efficacy of DNA vaccines is ultimately determined by professional antigen presenting cells, such as macrophages, dendritic cells, and Langerhans cells (Corr et al., 1996 Doe et al., 1996 Iwasaki et al., 1997 Ulmer et al., 1996). It follows that successful DNA vaccination strategies should seek to target DNA... 

The CD52 antigen, a 21- to 28-kDa glycopeptide, is expressed at high density on the surface of B- and T-l5miphocytes, macrophages, and monocytes, but not hematopoietic stem cells (33). It is also expressed on all CLL cells and indolent B-cell lymphoma cells. The entire structure of the CD52 molecule has been determined. However, its function still remains to be revealed. 

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