Macrophages armed

Steplewski Z, Lubeck MD, Koprowski H. Human macrophages armed with murine immunoglobulin G2a antibodies to tumors destroy human cancer cells. Science 1983 221 865-867. 

Dorio, RJ. and Forman, H.J., Ethanol inhibition of signal transduction in superoxide production by rat alveolar macrophages. A proposed mechanism for ethanol related pneumonia, Arm. Clin. Lab. Sci. 18, 3, 190, 1988. 

Variable Fragment (Fv) The tips of the two Y arms vary greatly from one antibody to another. They are the regions that bind to epitopes of antigens and bring them to the natural killer cells and macrophages for destruction. 

The native calcium-binding protease, calpain, which translocates to the cytosolic surface of membranes upon calcium binding, was enriched from a membrane preparation and shown to elicit high levels of protection (56-67%) in mice (Hota-Mitchell ef a/., 1997). This protein was first implicated in protective immunity as the target of a CD4+ T cell clone that could arm peritoneal macrophages to kill schistosomula in vitro (Jankovic ef a/., 1996). The same clone administered intraperitoneally, conferred 65% protection on irradiated mice challenged via this route with cercariae and recombinant IL-2 (this is a very artificial test from which results should be treated with caution). The large subunit of calpain was subse-... 

Colsky, A., and J. Peacock. 1991. Palmitate-derivatized antibodies can specifically arm macrophage effector cells for ADCC. J Leukoc Biol 49 1. 

Henkel JS, Errgelhardt JI, Siklos L, Simpson EP, Kim SH, Pan T, Goodman JC, Siddique T, Beers DR, Appel SH (2004) Presence of derrdridc cells, MCP-1, arrd aedvated microglia/macrophages in amyodophic lateral sclerosis spirral cord dssue. Arm Neurol 55 221-235. 

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