Antigen-bearing cells

In this type of reaction an antigen elicits the generation of cytotoxic T-lymphocytes ( immune defense). Cytotoxic T-lymphocytes (Tc) destroy antigen bearing cells by inducing apoptosis. This reaction can be viewed as the cellular counterpart to the humoral Type II reactions. They play an important physiological role in the defense of viruses, and can become allergic reactions under the same conditions as described for Type II reactions. 

Some experiments require that antigenic information be obtained from the surface of the cell others are interested in intramembrane antigens or intracellular antigens, or indeed the relationship of one antigen-bearing cell to another. The specimen can be prepared by one of several different methods to expose antigens and, thus, obtain the desired antigenic information from the sample (I). 

It has been known for some time that T. spiralis antigens localize to Nurse cell nuclei (Ooi and Kamiya, 1986 Despommier et al., 1990 Sanmartin et al, 1991) and recently it has been shown that some of these antigens bear Tyv (Yao et al., 1998). It has been proposed that these... 

Huh JC, Strickland DH, Jahnsen FL, Turner DJ, Thomas JA, Napoli S, Tobagus I, Stumbles PA, Sly PD, Holt PG Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma DC activation occurs in the airway mucosa but not in the lung parenchyma. J Exp Med 2003 198 19-30. 

Lederberg, J. (1959). Genes and antibodies do antigens bear instructions for antibody specificity or do they select cells lines that arise by mutation Science 129, 1649-1653. 

Holt, P.G., Schon-Hegrad, M.A. and Oliver, J. (1988). MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations. J. Exp. Med. 167, 262-274. 

Guilien, P., Avrameas, S., and Burtin, P. (1970) Spedfidty of antibodies in single cells after immunization with antigens bearing several antigenic... 

Cavanagh LL, Bonasio R, Mazo IB, Halin C, Cheng GY, van der Velden AWM, Cariappa A, Chase C, Russell P Starnbach MN, Koni PA, Pillai S, Weninger W, von Andrian UH (2005) Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells. Nat Immunol 6 1029-1037... 

---