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Macrophages antigen presentation

B5. Bakouche, O., and Lachman, L. B. Synthetic macrophages Antigen presentation by liposomes bearing class II major histocompatibility complex (MHC) and membrane interleukin-1 (IL-1). [Pg.55]

The antiinflammatory effects of statins likely result from their ability to inhibit the formation of mevalonic acid. Downstream products of this molecule include not only the end product, cholesterol, but also several isoprenoid intermediates that covalently modify ( pre-nylate ) certain key intracellular signaling molecules. Statin treatment reduces leukocyte adhesion, accumulation of macrophages, MMPs, tissue factor, and other proinflammatory mediators. By acting on the MHC class II transactivator (CIITA), statins also interfere with antigen presentation and subsequent T-cell activation. Statin treatment can also limit platelet activation in some assays as well. All these results support the concept that in addition to their favorable effect on the lipid profile, statins can also exert an array of antiinflammatory and immunomodulatory actions. [Pg.228]

Class 2 MHC molecules are expressed on the surface of B cells, macrophages, monocytes, various antigen-presenting cells (APCs) and certain cells of the T-cell famify. [Pg.294]

Immunopharmacology of Macrophages and other Antigen-Presenting Cells (edited by... [Pg.307]

Interleukin-10 (IL-10) affects antigen presentation capacity but also interferes with many other functions of monocytes and macrophages (Table 2) (F8). In vitro, IL-10 is a potent inhibitor of cytokine production, including production of TNF, IL-1, IL-6, and IL-8 by LPS-activated monocytes/macrophages (F8). It also inhibits tissue factor-dependent procoagulant activity induced by LPS in human... [Pg.65]

As stated earlier, dendritic cells and macrophages are valuable antigen-presenting cells (APCs). These cells express MBPs and, as such, they constitute important entry mechanisms for vaccine targeting. Thus, instead of linking short peptide antigens to... [Pg.317]

The activation of a T-cell response and subsequent efficacy of DNA vaccines is ultimately determined by professional antigen presenting cells, such as macrophages, dendritic cells, and Langerhans cells (Corr et al., 1996 Doe et al., 1996 Iwasaki et al., 1997 Ulmer et al., 1996). It follows that successful DNA vaccination strategies should seek to target DNA... [Pg.142]

The adjuvanticity of liposomes depends upon their composition, number of layers and charge characteristics. They act as effective adjuvants for both protein- and carbohydrate-based antigens and help stimulate both B- and T-cell responses. Their likely mode of action includes depot formation, but they also possibly increase/enhance antigen presentation to macrophages. The exact molecular mechanism(s) by which they stimulate a T-cell response remains to be elucidated,... [Pg.415]

It is reasonable to presume that the immunogenic and adjuvant activity of lipospheres may be the result of a combination of factors. These factors may include a focused and enhanced delivery of the antigen to an antigen-presenting cell (macrophage) and protection of the antigen from metabolic destruction at other sites in the body that do no participate in the immune response. [Pg.11]


See other pages where Macrophages antigen presentation is mentioned: [Pg.172]    [Pg.246]    [Pg.238]    [Pg.3921]    [Pg.28]    [Pg.8]    [Pg.172]    [Pg.246]    [Pg.238]    [Pg.3921]    [Pg.28]    [Pg.8]    [Pg.315]    [Pg.630]    [Pg.330]    [Pg.439]    [Pg.186]    [Pg.307]    [Pg.35]    [Pg.346]    [Pg.308]    [Pg.210]    [Pg.432]    [Pg.433]    [Pg.829]    [Pg.833]    [Pg.868]    [Pg.1241]    [Pg.156]    [Pg.197]    [Pg.257]    [Pg.350]    [Pg.351]    [Pg.303]    [Pg.316]    [Pg.176]    [Pg.11]    [Pg.57]    [Pg.206]    [Pg.645]    [Pg.199]    [Pg.183]    [Pg.64]    [Pg.132]    [Pg.134]    [Pg.158]    [Pg.193]    [Pg.214]   
See also in sourсe #XX -- [ Pg.132 ]




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