Macromolecular Drug Delivery

Table 15 Suggested Soluble Macromolecular Drug-Delivery Systems and Their Uses...

Swaan, P. W. Recent advances in intestinal macromolecular drug delivery via receptor-mediated transport pathways. Pharm. Res. 15 826-834, 1998. 

The lysosomal enzymes The lysosomes are membrane vesicles ubiquitous to mammalian cells and contain a panoply of hydrolytic enzymes, estimated to be over 60 in number, that function to digest practically any biological macromolecule. They are important to the discussion of oral macromolecular drug delivery for two reasons. First, any macromolecules that escape digestion by the pancreatic and brush border enzymes are likely to be taken up into the epithelial cells by the process of endocytosis. In this process, the apical membrane invaginates and the target molecules enter endocytic vesicles that then fuse with the lysosomes and are subjected to intracellular hydrolysis by the lysosomal enzymes. Second, the sloughing-off of the epithelial cells means that the lysosomal enzymes will be released into the lumen of the intestine. They may be... 

Oral Macromolecular Drug Delivery Systems Containing Low Molecular Mass... 

Table 5.1 Advantageous features of oral macromolecular drug delivery systems Demanded features Benefit Additional information...

Within the last decades strong evidence has been provided on the potential of various types of low molecular mass permeation enhancers to improve the oral uptake of macromolecular drugs. Nevertheless, so far no oral macromolecular drug delivery system comprising a low molecular mass permeation enhancer has entered the market indicating that the permeation-enhancing properties of these enhancers are still associated with too high toxic risks. 

Multifunctional Polymeric Excipients in Oral Macromolecular Drug Delivery... 

From Methods in Molecular Biology, vol. 480 Macromolecular Drug Delivery, Edited by M. Belting DOI 10.1007/978-1-59745-429-2 1, Humana Press,a part of Springer Science+Business Media, LLC 2009... 

Macromolecular Drug Delivery 2. Vehicles for Macromolecular Delivery... 

Ludwig, G., Strauss, L.G., and Dimitrakopoulou-Strauss, A. (2008) Positron emission tomography (PET) and macromolecular delivery in vivo, in Macromolecular drug delivery (Belting, M., ed.), Humana Press, pp. 187-198. 

The delivery of macromolecules into the central nervous system (CNS) via the blood stream is seriously limited by the blood-brain barrier (BBB). Noninvasive, transient, and local image-guided blood-brain barrier disruption (BBBD) can be accomplished using focused ultrasound exposure with intravascular injection of pre-formed microbubbles. A detailed description of the method for MRI-guided focal BBBD in animals will be described in this chapter. The method may open a new era in CNS macromolecular drug delivery. 

Macromolecular Drug Delivery Methods and Protocols, edited by Mattias Belting 2009 479. Plant Signal Transduction Methods and... 

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