Polyether macrolide

Bipyrrole alkaloids, cyclic peptides, quinones, macrolides, polyethers Vertebrata Osteichthyest, 22,000 spp. 

Jansen, R., Wray, V., Irschik, H., Reichenbach, H., and Hoefle, G. (1985). Antibiotics from gliding bacteria. XXX. Isolation and spectroscopic stracture elucidation of sorangicin A, a new type of macrolide-polyether antibiotic from gliding bacteria. Tetrahedron Lett. 26, 6031-6034. 

Nowadays, we have a wide range of antibiotics at our disposal. In general, these may be grouped into the following classes of compounds amino-glycosides, jS-lactams, chloramphenicol (first isolated from Streptomyces venezuelae), glycopeptides e.g. vancomycin), lincomycin, macrolides, polyethers and tetracyclines. 

Diastereo- and Enantioselective Aldol Reactions. Optically active 1,2-diol units are widely distributed in natural products such as macrolides, polyethers, and carbohydrates, etc. The aldol reactions of the enolates derived from a-alkoxyacetic acid ester derivatives with aldehydes provide a useful way to construct 1,2-diols, and several as)unmetric reactions have been developed. 

Because optically active molecules containing 1,2-diol units are often observed in nature (e.g. carbohydrates, macrolides, polyethers), asymmetric aldol reaction of the silyl enolate of a-benzyloxythioacetate 82 with aldehydes has been investigated for simultaneous introduction of two vicinal hydroxy groups with stereoselective carbon-carbon bond-formation. It has, interestingly, been found that the anti-a,fd-dihydroxy thioester derivatives 83 are... 

Isohomohalichondrin B Phase 1 Lissodendoryx sp. Anticancer Macrolide polyether... 

The Prelog-Djerassi lactone (abbreviated here as P-D lactone) was originally isolated as a degradation product during structural investigations of antibiotics. Its open-chain equivalent 3 is typical of the methyl-branched carbon chains that occur frequently in macrolide and polyether antibiotics. The compound serves as a test case for the development of methods of control of stereochemistry in such polymethylated structures. There have been more than 20 different syntheses of P-D lactone.24 We focus here on some of those that provide enantiomerically pure product, as they illustrate several of the methods for enantioselective synthesis.25... 

Acyclic stereocontrol has been a striking concern in modern organic chemistry, and a number of useful methods have been developed for stereoregulated synthesis of conformationally nonrigid complex molecules such as macrolide and polyether antibiotics. Special attention has therefore been paid to the aldol reaction because it constitutes one of the fundamental bond constructions in biosynthesis. 

Antibiotics, 11 867. See also Macrolide antibiotics Polyether antibiotics Tetracyclines... 

Tuz Golu (lake), 5 784 Tversky similarity, 6 8 T vessicant agent, 5 816 physical properties, 5 817t Twaron fiber, 13 373 Tween surfactants, 24 150 12-membered ring macrolides, 15 272, 275t 2,6-TDI, reaction with a polyether triol, 25 459. See also Toluene diisocyanate (TDI)... 

Boron is an essential trace element for plants, and may well turn out to be essential for mammals as well. The boron-containing polyether-macrolide antibiotic, boromycin, was isolated as a potent anti-HIV agent. 

Hirata Y, Uemura D. (1986) Halichondrins — antitumor polyether macrolides from a marine sponge. Pure Appl Chem 58 701-710. 

The Prelog-Djerassi lactone (abbreviated as P-D-lactone) was originally isolated as a degradation product during structural investigation of antibiotics. Its open-chain precursor 1, is typical of methyl-branched carbon chains that occur frequently in macrolide and polyether antibiotics. 

Bacterial metabolites include novel alkaloids, peptides, and macrocyclic lactams. The most unusual metabolites from dmoflagellate are polyethers, both linear and macrolides. The latter were also found abundantly in brown seaweeds (Chart 7.6.FA/PO). Filamentous fimgi have afforded new isoindole and quinazoline alkaloids, as well as new-skeleton steroids (Chart 7.6.A/P/I). 

Porif.> (hydro)pyrimidine, macroQ clic and oligomeric pyridine or pyridinium, naphthyridine, oxazole, pteridine, pyridoacridine, pyrrole, pyrroloimiiMquinone, (oxa)quinoli2idine, terpenoid indolizidine. ISOPR. Monotero. rare Sesouitem. . Ditero.. Sestertero. also degraded C>i Tritero.. POLYKET. macrolides, polyacetylenes, polycyclic (hydro)quinones, polyethers, (epidioxy)polyp ionates. ... 

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