Lysine dihydrochloride

The contents of the nucleic acid bases in the poly-L-lysine derivatives were determined by UV spectra of the polymers after hydrolysis The polymers were hydrolyzed in 6 N-hydrochloric acid at 105°C for 24 hr, into lysine dihydrochloride and the carboxyethyl derivatives of the nucleic acid bases. The quantitative calculation was made relative to the standard sample of the carboxyethyl derivative of the nucleic acid bases. The analytical data are listed in Table 1. It was found that the thymine and uracil derivatives was completely substituted to polylysine. Low value in case of adenine base in the polymer may be attributed to the unstability of the activated ester, Ade-PNP (2), and may also be explained in terms of the steric interaction among bulky pendant groups of the polymer. When the poly-L-lysine containing about 50 mol % adenine units was again treated with Ade-PNP, the adenine unit content in the polymer increased up to 74 mol %(,] ). 

The management of acute phencyclidine intoxication has been reviewed (29,30,31,32). Acidification of the urine enhances its renal clearance (33). All of the following have been used to achieve this ammonium chloride 1 g qds with sufficient water or cranberry juice lysine dihydrochloride 2 g tds with sufficient water or cranberry juice lysine hydrochloride 2 g qds with water or cranberry juice cranberry juice 18 or more oz/day alone or plus lysine, ammonium chloride, or ascorbic acid (34). 

The commercial operation must be capable of producing 9,000 metric tons of lysine (as lysine-dihydrochloride-H20) per year. With a 2.0 g/0.1 1 concentration of lysine in the fermentation broth, the number of liters of broth to be treated each year are ... 

B) dl-Lysine Dihydrochloride.—A solution of 100 g. (0.4 mole) of benzoyllysine in a mixture of 600 cc. of hydrochloric acid (sp. gr. 1.18) and 400 cc. of water is boiled under a reflux condenser for ten hours. The mixture is cooled and the benzoic acid removed by filtration. The filtrate is evaporated on a... 

L-Lysine monohydrochloride, C4H.5C1N202, Darryl, Eni-syl, Lyamine. Prepd by treating an ethanol soln of the dihy -drochloride with pyridine. Crystals from dil ethanol, mp 263-264 when anhydrous (L-lysine dihydrochloride dihy-drate, large crystals from water, mp 257°). [a] +14.6 ... 

D, L-Lysine dihydrochloride 23 Diethyl a-(acetylamino)-a-(3-cyanopropyl)malonate (15 g) is dissolved in freshly distilled acetic anhydride (100 ml), platinum dioxide (0.5 g) is added, and hydrogenation carried out at an initial pressure of 3 atm. Absorption is complete in 3 h. The catalyst is removed, and the acetic anhydride is hydrolysed by cautious addition of water (25 ml). The A,A-diacetyllysine is then cleaved by boiling it for 18 h in acetic acid solution containing concentrated hydrochloric acid (d 1.19 100 ml). Evaporation then affords d,l-lysine dihydrochloride (9g, 77%), m.p. 175-180°, which, after dissolution in anhydrous ethanol and precipitation by ether, melts at 187-188°. 

NHS)-ester of lysine dihydrochloride in the presence of a polyfiinctional core, using the slow monomer addition strategy. A self-evident method for preparing hh poly(lysine) by direct self-condensation was reported more recendy by Klok and co-workers. ... 

A -Lauroyl-L-arginine-lysine dihydrochloride 11 (CH2)4-NH3C1 Ci2ArgLys... 

The detail synthesis method described elsewhere [13]. In brief, a mixture of dianhydride, ethyl L-lysine dihydrochloride, EtsN in DMF and their respective concentration 0.001, 0.001, 0.002 mol was stirred at room temperature and then refluxed (Table 1). The product obtained after precipitation, filtration, and drying under vacuum. 

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