Lymphocytes adaptive immune response regulating

NF-kB regulates both innate and adaptive immune responses ( immune defense) [2]. Understanding the function of NF-kB in the development, maintenance, and activation of cells from the immune system (including hematopoietic cells, macrophages, dendritic cells, B and T lymphocytes) has greatly benefited from the analysis of knockout mice in which individual NF-kB family members were defective. 

Because the critical biological activities of LTB4 are geared toward peripheral blood leukocytes, including activation of neutrophils and lymphocytes, its role is predominantly in inflammation and secondarily in immune regulation at inflammatory sites (Figure 4). Its physiologic role relates directly to innate and adaptive host immune defense that depend on a controlled inflammatory response. 

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