Lupinus termis

Antoun, M. D. and Taha, O. M. A. 1981. Studies on Sudanese medicinal plants. II. Evaluation of an extract on Lupinus termis seeds in chronic eczema. Journal of Natural Products, 44 179-183. 

The qualitative and quantitative patterns of alkaloid content in the various organs of Lupinus termis Forsk., one of three Lupinus species indigenous to Egypt, have been studied. The maximum alkaloid content was observed in the seeds of very ripe fruits thirteen weeks after flowering at the same time the alkaloid content of the roots was at its minimum. Thin-layer chromatography provided evidence for the presence of nine alkaloids, of which the major one was identified as (+)-lupanine. A second alkaloid was reported to show the same chromatographic behaviour as 13-hydroxylupanine, but was not positively identified. This work confirms an earlier report d of the presence of these two alkaloids in Lebanese specimens of L. termis. 

Lupinus termis and related species accumulate a group of alkaloids possessing an unusual carbon skeleton, albine-type bases. In L. termis, (-)-albine (88) co-existed with (-)-multifloriiie (56), (-)-13a-hydroxymultiflorine (82) and (-)-ll,12-seco-12,13-didehydromultiflorine (83). The hypothetical biosynthetic mechanism is proposed to explain the substitution pattern of the propenyl side chain of 88 in relation to the coexistence of 82 and 83 (Fig. 8). In this proposed pathway, aza-Cope rearrangement is involved as the key step for formation of the allylic side chain at the unusual position, C-13. 83 can also be derived from the same pathway of biosyntliesis (84 83). This... 

Mishkinsky, J.S., A. Goldschmied, B. Joseph, Z. Ahronson, and EG. Suknan. 1974. Hypoglycaemic effect of Trigonella foenum-graecum and Lupinus termis (Leguminosae) seeds and their major alkaloids in alloxan-diabetic and normal rats. Arch. Int. Pharmacodyn. Ther. 210(l) 27-37. 

Samples of seeds of Vicia faba Vigna sinensis, Phaseolus vulgaris, Trigonella - Foenum graecum, Lupinus termis were mixed with aqueous solutions containing varying quantities of... 

The (-)-lupanine is hydrorhombinine and has been isolated from L. pussilus and Lupinus macouni as well as other species, such as Baptisia versicolor and Podalyria calyptrata. The melting point of (-)-lupanine is 190 In such species as L albus and L. termis lupanine occurs as ( )-lupanine with melting points of 127-128 °C and 250-252. In L polyphyllus Lindl., L. angustifolius... 

Lupinus (lupin) seeds are commonly taken as an appetizer in Southern Europe and the Middle East. Lupin flour has been used as a source of energy and protein (42,43). An extract of Lupus termis has been used to treat chronic eczema (44). 

In such species as L. albus and L. termis, lupanine oeeurs as ( )-lupanine with melting points of 127—128 ° C and 250-252 ° In L. polyphyllus Lindl., L. angustifolius L., and L. albus L., 17-oxolupanine has also been detected. Hydroxylupanine and their esters occur in Lupinus densiflorus, L. latifolius, Lupinus polycarpus, Lupinus ruber, Lupinus burkei L. rotundiflorus, L. montanus, L. exaltatus, L. mexicanus, L. madrensis and L. polyphyllus ... 

---