Lung cancer murine models

Keane MP, Belperio JA, Xue YY, Burdick MD, Strieter RM. Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer. J Immunol 2004 172(5) 2853-2860. 

Walser TC, Rifat S, Ma X, et al. Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer. Cancer Res 2006 66 7701-7707. 

Taking these factors into consideration, the intravenous administration of Hpoplex may represent a promising gene dehvery method to treat pulmonary diseases. Simple gene delivery can be an effective approach for the treatment of lung diseases, including pulmonary metastasis of tumor cells. Indeed, the intravenous administration of interferon (IFN)-/9- and interleukin (IL)-12-encoding pDNA has been shown to provide effective treatment in a murine pulmonary cancer metastasis model [27, 28]. 

Walser, T.C., Rifat, S., Ma, X.R., Kundu, N., Ward, C., Goloubeva, O., Johnson, M.G., Medina, J.C. et al. (2006) Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic hreast cancer. Cancer Research, 66, 7701-7707. 

Arenberg, D., Zlotnick, A., Strom, S., Burdick, M., and Stricter, R. (2001). The murine CC chemokine, 6C-kine, inhibits tumor growth and angiogenesis in a human lung cancer SCID mouse model. Cancer Immunol. Immunother. 49, 587-592. 

These early events also may be better modeled in murine models than late- stage lung cancer (see below). Thus, there is an inherent complexity in human lung cancer, and to precisely reeapitulate the disease process in animals is not yet possible. 

IIL Preclinical Murine Models of Human Lung Cancer Utilized in Studies of Gene Therapy... 

B. Spontaneously Arising Lung Cancer in Murine Models... 

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