Lunasia amara

A number of simple quinolines and quinolones have been isolated from various rutaceous plants, e.g., from angostura bark (Volume III, p. 80) and from Lunasia amara Blanco (Volume VII, p. 241 this chapter Section IV,A). The leaves of Haplophyllum dubium Eug. Kor (15, 16) contain dubamine (mp 96°-97°) which has been identified (17) as 2-(3,4-methylenedioxyphenyl)quinoline (I). Ruta graveolens L. contains, in addition to furoquinolines, the alkaloids graveoline (mp 205°) (18,19), and graveolinine (mp 115°-116°) (20), the latter (II) is also found in L. amara, and the former is the related l-methyl-4-quinolone (III). [Pg.224]

H. robustum Hortia arborea Lunasia amara Blanco Melicope fareana Engl. [Pg.229]

Although the presence of alkaloids in Lunasia amara Blanco has been long recognized and several bases were isolated and characterized during the first half of this century (Volume V, p. 316) the structures of only two had been elucidated by 1957 (Volume VII, p. 241) both of these being simple 2-arylquinoline derivatives (XXVII and XXVIII). Shortly... [Pg.236]

Alkaloids Isolated from Lunasia amara and Balfourodendron riedelianum ... [Pg.237]

Hydroxylunidonlne (41 ) occurs both in the stems and flowers of Lunasia amara, whereas 6-methoxylunidonine (42), 6-methoxylunidine (43) and 6-methoxyhydroxylunidine (44) have only been found in the stem of this plant (L.A. Mitscher et al., Lloydla, 1975, 28, 117 J.A. Reisch et ai., Phytochem., 1975, 14, 1678). [Pg.228]

A further study of the constituents of Ptelea trifoliata resulted in the isolation of lunidonine (2 R = Me), previously obtained from Lunasia amara, and of the new alkaloid, N-desmethyl-lunidonine (2 R = H). ... [Pg.108]

The 7,8-methylenedioxyhydroxyisopropyldihydrofuroquinolone alkaloid, (-)-hydroxylunine (55), was isolated from Lunasia amara (Volume IX, p. 245), and the (+) enantiomer has now been shown to be a constituent of Ptelea trifoliata (55). Mitscher et al. (54) obtained the corresponding quaternary salt, O-methylhydroxyluninium salt (56), from the stems of... [Pg.121]

The biosynthesis of isopropylfuroquinolines such as lunasine (338) and lunacrine (335) has been discussed (cf. 80), but not yet established their cooccurrence with hydroxy derivatives (cf. 333) in Lunasia amara and in Ptelea trifoliata suggests that the two groups of alkaloids are interrelated biosynthetically, for example by a pathway involving successive dehydration and reduction via terminal olefins (Scheme 29). This scheme is supported by the presence of terminal olefins in P. trifoliata but not by the stereochemistry of the alkaloids (-)-(R)-lunacrine (335) and... [Pg.187]

This alkaloid, one of several isolated from Lunasia amara Blanco, has been studied by Steldt and Chen (220). Lunamarine (1 200,000) powerfully stimulates the isolated rabbit uterus, the effect being most marked on the tonus. [Pg.196]

Bei der Kondensation von Anthranilsaure mit geeigneten Reaktions-partnem konnen weitere Alkaloidtypen gebildet werden. Fur die Chinolin-basen aus Lunasia amara (z.B. CCLIV) wird eine Bildung entsprechend Schema 44 angenommen (111, 255, 282, 342). [Pg.105]

Quinoline Alkaloids.—Anthranilic acid and a benzoylacetic acid derivative, derived from phenylalanine, are precursors for graveoline (124) cf. ref. 5. On the other hand, whilst the biosynthesis of (125) no doubt involves anthranilic acid, benzoic acid (carboxyl-labelled material), and not phenylalanine, was a precursor for (125) in Lunasia amara incorporation was specific, with labelling of C-2. The remaining carbons should derive from acetate, and a positive incorporation was recorded. It is clear that further work is required on the biosynthesis of this alkaloid before its origins can be described with certainty. [Pg.27]

Lunacridine 1-Me, 3-CH2CH(OH)CHMe2, 4,8-diOMe Lunasia amara, L. amara var. repanda, L. costulata [42], Zanthoxylum budrunga [37]... [Pg.723]

Lunidonine 1-Me, 3-CH2COCHMe2, 4-OMe, 7 OCH2O-8 Lunasia amara var. repanda [42], Orixa japonica [39], Ptelea trifoliata, P. trifoliata ssp. pallida var. [44]... [Pg.723]

Lunine II 2 -CHMe2, 7-OCH2O-8, 1-Me Lunasia amara, L. quercifolia [42], Ptelea trifoliata [42]... [Pg.730]

Ifflaiamine II l,2, 3, 3 -tetraMe Flindersia ifflaiana [42] Lunasia amara [50]... [Pg.730]

Methoxy-2- phenylquinoline 4-OMe, Lunasia amara [2, 41], Galipea longiflora [41]... [Pg.785]

See also in sourсe #XX -- [ Pg.223 , Pg.224 , Pg.229 , Pg.236 , Pg.237 ]

See also in sourсe #XX -- [ Pg.228 ]

See also in sourсe #XX -- [ Pg.72 ]

See also in sourсe #XX -- [ Pg.316 ]

See also in sourсe #XX -- [ Pg.571 ]

See also in sourсe #XX -- [ Pg.211 ]

See also in sourсe #XX -- [ Pg.151 , Pg.152 , Pg.153 ]

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