LuCls

Strand, S.-E. and B. R. R. Petsson. 1979. Quantitative lymphoscintigraphy I basic concepts for optimal uptake of radiocolloids in the parasternal lymph nodes of rabbLt lucl. Med20 1038-1046. 

Lithography, 336,365 Long forms of the periodic table, 81 LRET. See Luminescence resonance energy transfer Lu, 124 Lu(OH)3, 327 Lu Cgz, 126 LuCls, 80... 

Figure 46 Me2Si(C5H2-3,5- BuMe)[l-C9H5-3-(CH2)2NMe2]L LuCl...

It is, however, possible to evade some of these difficulties arising from nonlinearity by use of the various forms of transformation mentioned in Chapter IX (b) and Chapter X (b). It -will be noted that the satisfactory use of these devices is based on our initially selecting the appropriate transformation, ather from physico-chemical knowledge of the system, or finrn an intelligent or lucl inspection of the data. If we have to try first one transformation, then another and so on till we get a good fit the amoimt of -work is excessive. 

LisN, Lithium nitride, 22 48 LuCL, Lutetium chloride, 22 39 LuC1sCs2, Cesium lutetium chloride, 22 6 LuCLCs3, Cesium lutetium chloride, 22 6 LuF,gNs06Pi2CnH72, Lutetium(IIl), hex-akis(diphenylphosphinic amide)-, tris(hexafluorophosphate), 23 180 LuNsOisCgHig, Ytterbium(III), trini-... 

Analyses of radiochemical purity were performed by solid phase extraction (SepPak C18 cartridge, Waters), TLC and reversed phase HPLC. An aliquot of 0.1 mL of the labelled peptide was loaded on the preconditioned SepPak cartridge, followed by addition of 5 mL of ImM HCl to elute LuCls or Tc. The labelled peptide was eluted with 3 mL of ethanoksaUne (1 1). 

The peptides were dissolved in DMSO and then diluted with O.IM ammonium acetate buffer (AAB) at pH6.5 to obtain lOmM stock solutions in AAB (10% DMSO) the peptides were stored at -126°C. Prior to labelling, the peptides were thawed and diluted to ImM in AAB containing 10% gentisic acid. Typically, 2-5 gL of "LuCl, (11-229 MBq, 0.3-6.2 mCi) was added to 5-10 gL of the peptide P3, P4 or octreotide, followed by addition of 80-188 gL of O.IM AAB with 10 mg/mL gentisic acid. The pH was measured and adjusted within a range of 4.0-5.5 with AAB the solution was subsequently incubated at 70°C for 30 min. The effect of temperature (40-70°C) and incubation time (10-60 min) was studied for Lu-P3. 

The impurities from accompanying trace levels of metal contaminants in the radionuclide solution, mainly iron and zinc, are critical for the labelling yields. If the level of either metal contaminant exceeds 1 pg/Ci, the labelling yields will be adversely affected. With reputed commercial suppliers, specific activities of 1 mCi/pg can be routinely obtained. A value lower than this reference specific activity can be indicative of the presence of the above metal impurities. The level of impurities can be reduced by passing the LuCl, or °YCl3 solutions through a cation exchange column (such as Chelex) that retains the other metal contaminants and effects purification. 

Bis(indenyl)ethane-derived aasa-lanthanidocenes [rac-and /He50-(CH2)2( -C9H6-l)2LnCl][LiCl(Et20)2] (Ln = Yb, Lu) were synthesized from dUithiated 1,2-bis(indenyl)ethane with either YbCla or LuCL in THF followed by solvent exchange with Et20. In the Yb case, the major diastereomer formed is meso, whUe in the case of Lu, the rac diastereomer predominated. 

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