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Lowest analytically quantifiable level

The repeatability and stability studies were done at concentration levels which preliminary evidence on liquid samples had shown to be reproducible within 10% CV. However, this was not the case for three of the dyes (C.I. Direct Red 28, C.I. Direct Brown 95, and C.I. Direct Black 38). In this situation, the lowest analytically quantifiable limit (LAQL) had to be redefined. From the results of the repeatability study, the second highest level was the logical choice for this redefined LAQL. A second abbreviated stability study was conducted with C.I. Direct Red 28, C.I. Direct Black 38, and... [Pg.31]

The limit of detection (LOD) or detection limit of a method is the lowest analyte concentration that the detector wiU produce a response detectable above the background, or noise level, of the system. The minimum detectable level (MDL) is the concentration level at the LOD and generally defined as three times the noise level (baseline) of the detector. LOD and MDL are the two quantifiable values that can measure the sensitivity of the method. Sensitivity is the smallest difference in the response of the detector (signal) that can be detected for the method. LOD is the smallest amount that is clearly distinguishable from the background or blank. [Pg.980]

Finally, it is important to define the lowest level of method validation (LLMV). The LLMV is defined as the lowest concentration level expressed in terms of amount of analyte in the matrix, at which the method (extraction/analysis procedure) was validated or proven to be capable of reliably quantifying. [Pg.64]

As the name implies the LoD describes the lowest concentration that can be detected with a certain level of confidence. From here we can state that the analyte is really present. This does not mean that we can quantify the content of the analyte with a certain confidence. This is only possible at concentrations above the LoQ. [Pg.193]

Where measnrements are made at low concentration levels, e.g. in trace analysis, it is important to know what is the lowest concentration of the analyte that can be confidently detected by the method. Forvahdation purposes it is normally sufficient to provide an indication of the level at which detection becomes problematic. Limit of detection is the lowest concentration of analyte in a sample that can be detected, but not necessarily quantified under the stated conditions of the test. [Pg.227]

The decision limit CCa is the limit at and above which it can be concluded with an error probability of a that a sample is noncompliant. If a permitted limit (PL) has been established for a substance (group or the regulated compounds), the result of a sample is noncompliant if the decision limit is exceeded (CCa = xPL + 1. 64vMri.). If no permitted limit has been established (group A), the decision limit is the lowest concentration level at which the method can discriminate with a statistical certainty of 1-a that the particular analyte is present (CCa = + 2.33.vs impic). The detection capability CCp is the smallest content of the substance that may be detected, identified, and/or quantified in a sample with an error probability of p (CCp = CCa + 1.65xsampie). [Pg.775]

The limit of quantification, LOQ, is a figure of merit that expresses the ability of a measurement process to quantify adequately an analyte and it is defined as the lowest amount or concentration of analyte that can be determined with an acceptable level of precision and accuracy [73]. In practice, the... [Pg.231]

Typically, laboratories choose the analyte PQL value at 2-10 times its MDL. The selection, however, is not entirely arbitrary because the laboratories must use the selected PQL concentration value as the lowest standard in the multipoint calibration curve. This enables the laboratory to assure that even at a low concentration level, the analyte is detected, identified, and quantified correctly. Therefore, the PQL may be also defined as a concentration that is 2-10 times greater than the MDL and that represents the lowest point on the calibration curve during routine laboratory operations. [Pg.241]

Quantitative Analysis. To study those factors that influence the occurrence of methoxypyrazines, it was necessary to be able to quantify them. Furthermore, it was desirable that this be possible even at the lowest levels that might be relevant. This indicated a need for their quantitative analysis to extend to concentrations below their sensory detection threshold of 1-2 ng/L, preferably by an order of magnitude. Accurate quantitative analysis at such extremely low analyte concentrations is difficult to achieve. If a moderate sample size is to be used, and if the analysis is to cope with some losses in isolation, then the technique needs to have a detection limit of a few picograms. Furthermore, it must provide quantitative data with adequate accuracy and precision for meaningful interpretation. [Pg.32]

The LOQ is the lowest level of analyte that can be quantified reliably, given aknown number of target taxon genome copies (EC Recommendation 2004/787/EC). In the context of the study, the LOQ corresponds to the lowest level of analyte for which relative standard deviation within the laboratory (RSDf) is 30% or less. Taking this into consideration, real-time PCR systems have absolute LOQs in the range 10 to 100 genome copies (data not shown). [Pg.150]

The limit of detection (LoD) represents the minimum concentration at which the presence of the analyte can be distinguished from its absence with a high statistical probability. There are different possible ways to define the LoD pivoting about the interpretation of significantly different from the blank. The choice of definition will influence which type of error is more likely Type I, false positives or Type II, false negatives. In addition to these considerations, the suitability of a specific LoD is of course affected by the chosen instrumentation and analytical method. Conversely, at higher levels the concentration of an analyte can be quantified. The lowest concentration that can be reliably quantified is known as the limit of quantification (LoQ). The LoQ is often set at a fixed multiple (usually between 2 and 3.3) of the LoD. [Pg.216]

Definition The detection limit of an individual analytical procedure is the lowest amount of an analyte in a sample, which can be detected but not necessarily quantified as an exact value. Description The limit of detection, expressed as a concentration or a quantity, is derived from the smallest signal xl, which can be detected with a reasonable certainty for a given analytical procedure xi = Xbi+ kshi, where Xbi is the mean and 5 1 the standard deviation of the blank measurements and kisa numerical factor chosen according to the level of confidence required. For many purposes the limit of detection is taken to be ... [Pg.148]


See other pages where Lowest analytically quantifiable level is mentioned: [Pg.50]    [Pg.50]    [Pg.230]    [Pg.773]    [Pg.371]    [Pg.360]    [Pg.21]    [Pg.362]    [Pg.4456]    [Pg.536]    [Pg.223]    [Pg.145]    [Pg.425]    [Pg.480]    [Pg.956]    [Pg.2128]    [Pg.472]   
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Lowest analytically quantifiable

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