Long-term potentiation impairment

Frankiewicz, T, and Parsons. C. G. (1999). Memantine restores long term potentiation impaired by tonic (V-methyl-u-aspanaie (NMDA) receptor activation following reduction of Mg in hippocampal slices. Neumpitarmacology 3S, 12.53-1259. 

Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1 -dependent mechanisms. 

Lanahan A et al. Selective alteration of long-term potentiation-induced transcriptional response in hippocampus of aged, memory-impaired rats. J Neurosci 1997 17 2875-2885. 

Haul S, Schrader J, Haas HL, Luh-mann HJ. Impairment of neocortical long-term potentiation in mice deficient of endothelial nitric oxide synthase. J Neurophysiol 1999 81 494—497. 

Villacres, E., Wong, S. T., Chavkin, C. and Storm, D. R. Type I adenylyl cyclase mutant mice have impaired mossy fiber long-term potentiation. /. Neurosci. 18 3186-3194,1998. 

Kojima, N., Wang, J., Mansuy, I. M. et al. Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing fyn transgene. Proc. Natl Acad. Sci. U.S.A. 94 4761—4765,1997. 

Migaud, M., Charlesworth, P., Dempster, M. et al. Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein. Nature 396 433-439, 1998. 

Morris RGM (1989) Synaptic plasticity and learning selective impairment of learning in rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist APS. J Neurosci 9 3040-3057... 

Korte M, Carroll P, Wolf E, et al Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc Natl Acad Sci U S A 92 8856-8860, 1995... 

The development of natural products having alleviation properties for the symptoms of learning and memory impairments has been clinically expected. In the brain, the hippocampus is a very important region in the learning and memory processes, and the long-term potentiation (LTP) induced from the brain tissue is closely related to learning and memory [10]. 

Moriguchi S., Han F., Nakagawasai O., Tadano T., and Fukunaga K. (2006). Decreased calcium/calmodulin-dependent protein kinase II and protein kinase C activities mediate impairment of hippocampal long-term potentiation in the olfactory bulbectomized mice. J. Neurochem. 97 22-29. 

Chen, Q. S., Kagan, B. L., Hirakura, Y., and Xie, C. W. (2000). Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides. J Neurosci Res 60, 65-72. 

Morris, R. G., Anderson, E., Lynch, G. S., and Baudry, M. (1986). Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 319, 774-776. 

Nomura, I., Kato, N., Kita, T., and Takechi, H. (2005). Mechanism of impairment of long-term potentiation by amyloid beta is independent of NMDA receptors or voltage-dependent calcium channels in hippocampal CA1 pyramidal neurons. Neurosci Lett 391, 1—6. 

Platt B, Carpenter DO, Busselberg D, et al. 1995. Aluminum impairs hippocampal long-term potentiation in rats in vitro and in vivo. Exp Neurol 134 73-86. 

Storm DR, Hansel C, Hacker B et al (1998) Impaired cerebellar long-term potentiation in type I adenylyl cyclase mutant mice. Neuron 20 1199-1210 Strittmatter SM, Valenzuela D, Kennedy TE et al (1990) GO is a major growth cone protein subject to regulation by GAP-43. Nature 344 836 11... 

Curran B, O Connor JJ (2001) The pro-inflammatory cytokine interleukin-18 impairs long-term potentiation and NMDA receptor-mediated transmission in the rat hippocampus in vitro. Neuroscience 108 83-90... 

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