Long-acting anticholinergic

Long-Acting Anticholinergic Tiotropium Inhalation 30 minutes 1-4 hours 24 hours Powder (18 mcg/inhalation) 1 inhalation every 24 hours... 

Saberi F, O Donnell DE. The role of tiotropium bromide, a long-acting anticholinergic bronchodilator, in the management of COPD. Treat Respir Med. 2005 4 275-281. 

Tiotropium bromide is a long-acting anticholinergic bronchodUator that binds with similar affinity to the three muscarinic receptor subtypes (SEDA-20, 190) (1). However, it dissociates more slowly from Mi and M3 receptors in bronchial smooth muscle than from M2 receptors (1). This results in a long half-hfe of the bound complex, allowing once-daUy administration. 

ATROPINE (SEE AOS) Atropine is a long-acting anticholinergic, which is used therapeutically in cases of iritis (inflammation of iris) and iridocyclitis (inflammation of iris and corpus ciliare), but for diagnostic purposes a... 

Tiotropium A potential association with cardiovascular risk has been suggested for long-acting anticholinergic drugs. In a 2-year randomized controlled study of the benefits of tiotropium versus fluticasone and salmeterol in 1323 patients with severe COPD, tiotropium was associated with significantly increased mortality (3% versus 6%), with an increase in cardiac events [86 ]. However, in a case series that specifically studied stroke in relation to tiotropium, there was no association [87 ]. 

Tiotropium is a long-acting inhaled anticholinergic available in a DPI it has an onset of action of approximately 30 minutes and a duration of action longer than 24 hours.32 Because pure asthmatics were excluded from clinical trials for tiotropium, a paucity of data exist concerning its use in asthma. 

Mechanism of Action An anticholinergic that binds to recombinant human muscar-inicreceptors at the smooth muscle, resulting in long-acting bronchial smooth-muscle relaxation. Therapeutic Effect Relieves bronchospasm. 

Tiotropium is a QTA representing a synthetic ester of N-methylated scopine (Fig. 1). This drug is clinically used as anticholinergic long-acting bronchodilator applied once daily as aerosolized solution to treat airway diseases such as COPD. Tiotropium is considered as a selective inhibitor of MR subtype Ml and M3 thus not enhancing mucus production [31]. 

Long-acting inhaled bronchodilators (beta2-agonists or anticholinergics) should be used to control symptoms and improve exercise capacity in patients who continue to experience problems despite the use of short-acting dmgs. 

It is a long-acting, nonsedating tricyclic antihistaminic drug. It possesses praetieally little anticholinergic activity. It shows potency that is fairly comparable to astemizole and signifieantly greater than terfenadine. ... 

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