Lodoxamide

Lodoxamide Mast cell stabilizer May be used for up to 3 months... 

Lodoxamide 1-2 drops in affected eye(s) four times daily Ocular stinging, foreign body sensation... 

Lodoxamide (Alomide) Mast cell stabilizer Ophth soln 0.1% [10 mL] ... 

Pharmacology Lodoxamide is a mast cell stabilizer that inhibits the in vivo Type I immediate hypersensitivity reaction. Although lodoxamide s precise mechanism of action is unknown, the drug may prevent calcium influx into mast cells upon antigen stimulation. 

Pharmacokinetics The disposition of lodoxamide was studied in 6 healthy adult volunteers receiving a 3 mg oral dose. Urinary excretion was the major route of elimination. The elimination half-life was 8.5 hours in urine. In a study in 12 healthy adult volunteers, topical administration of 1 drop in each eye 4 times/day for 10 days did not result in any measurable lodoxamide plasma levels at a detection limit of 2.5 ng/mL. 

Contact lenses As with all ophthalmic preparations containing benzalkonium chloride, instruct patients not to wear soft contact lenses during treatment with lodoxamide. 

Lactation It is not known whether lodoxamide is excreted in breast milk. 

Burning/Stinging Patients may experience a transient burning or stinging upon instillation of lodoxamide. Should these symptoms persist, advise patients to contact their physicians. 

Ketorolac, Ophthalmic (Acular, Acular LS, Auclair PF) Ketotifen (Zaditor) Levocabastine (Livostin) Lodoxamide (Alomide)... 

Lodoxamide (Alomide) [Antihistamine] U e V nal conjunc-Action Stabilizes mast cells Dose Adults Feds >2 y. 1-2 gtt in eye(s) qid = 3 mo Caution [B, ] Disp Soln SE Ocular burning, stinging, HA EMS None OD Unlikely... 

Contraindications Wearing soft contact lenses (product contains benzalkonium chloride), hypersensitivity to lodoxamide tromethamine or any component of the formulation... 

Hypotension induced by APNEA could be blocked by the mast cell stabilizing agents, disodium cromoglycate and lodoxamide. 

Topical mast cell stabilisers are best used for prophylaxis of allergic eye symptoms. Sodium cromoglicate is effective in most people. Lodoxamide and nedocromil are more expensive, but may be worth trying in people with inadequate response to sodium cromoglicate. Mr JA cannot use eye drops because he wears contact lenses therefore nasal corticosteroids are recommended. 

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