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Lodoxamide tachyphylaxis

Figure 4. Effect of muscarinic blockers atropine and QNB on multiple-dose lodoxamide tachyphylaxis. Sensitized rats were given atropine 25mglkg ip or QNB 0.01 mg/kg ip 20 min before the first iv dose of lodoxamide. One hr Utter the animals were given another iv dose of lodoxamide (0.2 mg/kg containing 2 mg egg albumin and S mg Evans blue), and 30 min later the skin sites of sensitization were scored and compared to nonpredosed rats as well as control rats. Numbers in parenthesis refer to number of animals per variable. Figure 4. Effect of muscarinic blockers atropine and QNB on multiple-dose lodoxamide tachyphylaxis. Sensitized rats were given atropine 25mglkg ip or QNB 0.01 mg/kg ip 20 min before the first iv dose of lodoxamide. One hr Utter the animals were given another iv dose of lodoxamide (0.2 mg/kg containing 2 mg egg albumin and S mg Evans blue), and 30 min later the skin sites of sensitization were scored and compared to nonpredosed rats as well as control rats. Numbers in parenthesis refer to number of animals per variable.
The Effect of Pretreatment of Rats with the Muscarinic Blockers Atropine and QuinuclicHnyl Benzilate (QNB) on Multiple Dose DS and Lodoxamide Tromethamine Tachyphylaxis... [Pg.82]

Rats dosed twice with inhibiting doses of either DSCG or lodoxamide tromethamine show tachyphylaxis to an inhibition of the subsequent passive cutaneous anaphylaxis assay (10.11,13 16,17). Atropine (25 mg/kg) or QNB (0.01 mg/kg) given ip 20 min prior to the first iv dose of DSCG or lodoxamide, partially blocked this multiple dose tachyphylaxis (13,16,17,27). Atropine or QNB by themselves at these concentrations had no inhibitory effect on the PCA reaction, but markedlv reduced (or almost totally eliminated) the tachyphylaxis (Fig. 3,4) to DSCG and to a lesser... [Pg.82]

These data indicate that DSCG and lodoxamide tromethamine exhibit biphasic dose responses for inhibition of mediator release and that both a portion of the bell-shaped curve and a part of the multiple dose tachyphylaxis can be blocked by prior treatment with atropine. [Pg.87]

Multiple doses of DSCG and other similar conpounds have been shown to develop a time and dose related period of tachyphylaxis in rats and primates, (12. 17. 23). Lodoxamide tromethamine also showed a similar phenomenon when multiple oral doses of 50 mg/kg were given (Table 14). Tachyphylaxis was evident if a hi dose (50 mg/kg) preceded a similar hi dose. Several low doses (0.1 mg/kg) appeared to give good inhibition in this assay. [Pg.90]


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