Lodoxamide effect

Topical mast cell stabilisers are best used for prophylaxis of allergic eye symptoms. Sodium cromoglicate is effective in most people. Lodoxamide and nedocromil are more expensive, but may be worth trying in people with inadequate response to sodium cromoglicate. Mr JA cannot use eye drops because he wears contact lenses therefore nasal corticosteroids are recommended. 

Although lodoxamide has a mechanism of action similar to that of cromolyn, this compound is 2,500 times more potent in its ability to inhibit mediator release. In addition to its mast cell stabilization effect, clinical improvement with the drug is also associated with inhibition of eosinophil migration and decrease in levels of leukotrienes (LTB4 and LTC4) and other inflammatory cells after allergen exposure. 

Ahmet A, Irkec M, Orhan M, et al. Effect of lodoxamide on tear leukotriene levels in giant papillary conjunctivitis associated with ocular prosthesis. Ocul Immunol Inflamm 1998 6 179-184. 

Capron M, Loiseau S, Papin JR et al. Inhibitory effect of lodoxamide on eosinophU activation, hit Arch AUergy Immunol 1998 116 140-146. 

Yanni JM,Weimer LK, Glaser RL, et al. Effect of lodoxamide on in vitro and in vivo conjunctival hypersensitivity response of rats. Int Arch Allergy Immunol 1993 101 102-126. 

The Effect of Muscarinic Blockers on the DSCXS and Lodoxamide Tromethamine Dose Response in Rat Mast Cell... 

The Effect of Pretreatment of Rats with the Muscarinic Blockers Atropine and QuinuclicHnyl Benzilate (QNB) on Multiple Dose DS and Lodoxamide Tromethamine Tachyphylaxis... 

Rats dosed twice with inhibiting doses of either DSCG or lodoxamide tromethamine show tachyphylaxis to an inhibition of the subsequent passive cutaneous anaphylaxis assay (10.11,13 16,17). Atropine (25 mg/kg) or QNB (0.01 mg/kg) given ip 20 min prior to the first iv dose of DSCG or lodoxamide, partially blocked this multiple dose tachyphylaxis (13,16,17,27). Atropine or QNB by themselves at these concentrations had no inhibitory effect on the PCA reaction, but markedlv reduced (or almost totally eliminated) the tachyphylaxis (Fig. 3,4) to DSCG and to a lesser... 

Figure 4. Effect of muscarinic blockers atropine and QNB on multiple-dose lodoxamide tachyphylaxis. Sensitized rats were given atropine 25mglkg ip or QNB 0.01 mg/kg ip 20 min before the first iv dose of lodoxamide. One hr Utter the animals were given another iv dose of lodoxamide (0.2 mg/kg containing 2 mg egg albumin and S mg Evans blue), and 30 min later the skin sites of sensitization were scored and compared to nonpredosed rats as well as control rats. Numbers in parenthesis refer to number of animals per variable.

Effect of Lodoxamide Guanylate Cyclases on Rat Lung Adenylate and (Basal Activity = 100%) ... 

We have reported studies on the effect of drugs on various lung parameters induced by Ascaris sensitivity (17.22). We quantitated these parameters and adapted the syston to test cromolyn Na by aerosol and intravenous administration as well as lodoxamide tromethamine. Lodoxamide tromethamine in this assay showed quantitative advantages to cromolyn Na (DSCX3) because it was significantly more active and was orally adsorbed. 

When lodoxamide tromethamine was administered orally to reactor Ascaris monkeys, excellent inhibition of both lung function parameters was seen Indicating a reversal of antigen challenge induced changes. Table 11 summarizes the activity of lodoxamide tromethamine and its duration of effect vAien dosed orally. This table also shows that when the optimal time (30 min.) is used to assay a dose response, inhibition can be seen as low as 5.0 mg/kg. Table 12 shows that when lodoxamide tromethamine was administered i.v. 5 min. before ascaris aerosolization (0.16 ml aerosolized in 50 respirations), protection was seen even at 0.001 mg total dose per animal (Table 13). 

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