Lodin chlorid

Cinnolin-4(lF/)-one and its 6-chloro, 6-bromo, 6-nitro and 8-nitro derivatives react with sulfuryl chloride or bromine in acetic acid to give the corresponding 3-halo derivatives in about 20% yields. lodination of 8-hydroxycinnolin-4(lF/)-one with a mixture of potassium iodide and potassium iodate gives the 5,7-diiodo derivative the 6,8-diiodo derivative is formed from 5-hydroxycinnolin-4(lF/)-one. 

Crich and Rumthao reported a new synthesis of carbazomycin B using a benzeneselenol-catalyzed, stannane-mediated addition of an aryl radical to the functionalized iodocarbamate 835, followed by cyclization and dehydrogenative aromatization (622). The iodocarbamate 835 required for the key radical reaction was obtained from the nitrophenol 784 (609) (see Scheme 5.85). lodination of 784, followed by acetylation, afforded 3,4-dimethyl-6-iodo-2-methoxy-5-nitrophenyl acetate 834. Reduction of 834 with iron and ferric chloride in acetic acid, followed by reaction with methyl chloroformate, led to the iodocarbamate 835. Reaction of 835 and diphenyl diselenide in refluxing benzene with tributyltin hydride and azobisisobutyronitrile (AIBN) gave the adduct 836 in 40% yield, along with 8% of the recovered substrate and 12% of the deiodinated carbamate 837. Treatment of 836 with phenylselenenyl bromide in dichloromethane afforded the phenylselenenyltetrahydrocarbazole 838. Oxidative... 

IODO-GEN (l,3,4,6-tetrachloro-3-6-diphenylglycouril) is a better reagent for the lodination of proteins than chloramine-T, is less damaging, and has fewer side reactions than the latter. The insolubility of IODO-GEN in water means that tubes can be precoated with the reagent dissolved in methylene chloride or chloroform. Then the tubes are stored in the dark until required. The reaction is started by adding the protein and radioiodide, and terminated by removing the sample from the reaction vessel. 

Sonochemistry has been applied to acceleration of the Reformatsky reaction, Diels-Alder reactions, the arylation of active methylene compounds nucleophilic aromatic substitution of haloarenes, and to hydrostannation and tin hydride reduction. " Other sonochemical applications involve the reaction of benzyl chloride and nitrobenzene, a Sr I reaction in liquid ammonia at room temperature, and Knoevenagel condensation of aromatic aldehydes. lodination of aliphatic hydrocarbons can be accelerated, and oxyallyl cations have been prepared from ot,ot -diiodoketones using sonochemistry. Sonochemistry has been applied to the preparation of carbohydrate compounds.When sonochemistry is an important feature of a chemical reaction, this fact will be noted in the reactions presented in Chapters 10-19. 

See Halogens, or Interhalogens, above Chromy 1 chloride Organic solvents Fluorine nitrate Organic materials Hydrogen peroxide Diethyl ether lodine(Vll) oxide Diethyl ether Lithium perchlorate Diethyl ether Nitric acid Diethyl ether Nitrosyl perchlorate Organic materials Nitryl perchlorate Organic solvents Ozone Diethyl ether... 

Emissions from both the and the previously unreported lli states of the IF molecule have been observed in the gas-phase reaction of L with F2 at low pressure a four-centre complex has been proposed as the reaction intermediate. A combined theoretical-experimental programme has been conducted to establish techniques for the study of excited-state transitions in Ij and IC1. Experimental techniques based on two-step excitation using two synchronized, tunable lasers have been developed, and successfully applied to excited-state fluorescence measurements on ICl. lodine(i) chloride adsorbed on silica gives the same Raman spectrum as that obtained from adsorbed l2. ... 

V. SULFONYL HALIDES AS SYNTHONS A. lodination of Sulfonyl Chlorides... 

Iodine, 72, 293-295, 333, 452,579 Iodine-Dimethyl sulfoxide, 295 Iodine-Potassium iodate, 296 Iodine-Pyridine N-oxide, 296 lodine-Pyridine-Sulfur dioxide, 296 Iodine azide, 297 Iodine bromide, 297 lodoacetonitrile, 494 a-lodo acyl chlorides, 116 o-Iodoanisole, 130 lodobenzene, 130, 443 7r-(Iodobenzene)chromium tricarbonyl, 104 lodobenzene diacetate-Trimethylsilyl azide, 297... 

Indole alkaloids, 233 Indole-3-carbonitriles, 106 lndole-3-carboxamides, 106 Indolenine alkaloids, 232 Indoles. 293, 518 Indoline, 50 Indolines, 46 Iodine, 235, 256-260 lodine-Copper(lI) acetate, 260 lodine-Thalliumfl) acetate, 260 Iodine azide, 260-261 Iodine chloride, 261 (l-Iodo-l-alkenyl)silanes, 104 lodobenzene diacetate, 351 lodocyclization, 259 trans, vic-Iodohydrins, 258 a-lodo ketones, 260, 442 lodolactonization, 257, 258... 

The attempted direct chlorination of compounds 358, 359 and 360 resulted in tarring. However, a reaction with sulphuryl chloride in acetic acid afforded 7-chloro derivatives 361, 364 and 367 in 4—90% yields. lodination of the same bases occurred quite easily on treating them with iodine in aqueous alkali to form iodo derivatives 363, 366 and 369 (60-88%). Substitution occurs in the 7th position of the IcP molecule, as in the case of chlorination and bromination. In the PMR spectra of all halides 361-369, only a singlet of 6-H at 7.77—7.91 ppm (in CF3COOH) appears (94KG1076). Bromination of 4-ethoxy-l,3-dimethyl-IcP-2-one (371) proceeds very easily to give its 7-bromo derivative 372 in 87% yield. This compound was also obtained when nitro compound 357 was treated with ethanolic alkali (94KG1076). 

Selective iodination of phenols, lodination of phenols with iodine results iiiiiinly in /xn-n-siibsliUilion iodination with thallium(l) acetate and iodine in wc( acetic acid or in melhylenc chloride results mainly in ort/io-substitution. 

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