Locally model-identifiable

A parameter 0 of 0 is locally model-identifiable at 0 for model class C and input F if it is model-identifiable but not globally model-identifiable. 

Text mining of literature for all biological context for target Use in silico model to identify potential issues Gather data for in silico prediction (local model) In silico prediction (local model) Set up in vitro screen to select a safer compound Predict relevance of such toxicity in human... 

Thus, the user can input the minimum site boundary distance as the minimum distance for calculation and obtain a concentration estimate at the site boundary and beyond, while ignoring distances less than the site boundary. If the automated distance array is used, then the SCREEN model will use an iteration routine to determine the maximum value and associated distance to the nearest meter. If the minimum and maximum distances entered do not encompass the true maximum concentration, then the maximum value calculated by SCREEN may not be the true maximum. Therefore, it is recommended that the maximum distance be set sufficiently large initially to ensure that the maximum concentration is found. This distance will depend on the source, and some trial and error may be necessary however, the user can input a distance of 50,000 m to examine the entire array. The iteration routine stops after 50 iterations and prints out a message if the maximum is not found. Also, since there may be several local maxima in the concentration distribution associated with different wind speeds, it is possible that SCREEN will not identify the overall maximum in its iteration. This is not likely to be a frequent occurrence, but will be more likely for stability classes C and D due to the larger number of wind speeds examined. 

TNF was originally identified because of its cytotoxic activity against some tumor cell lines and its ability to induce hemorrhagic necrosis of solid tumors in various animal models. However, the clinical use of TNF as an anticancer drug has been so far limited by its severe cardiovascular side effects. Therefore, TNF treatment is limited to regional and local administration of high doses of TNF, often in combination with chemotherapy, as accomplished in isolated limb and isolated hepatic perfusion (ILP and IHP, respectively) [5]. In the case of ILP, typically metastases are treated, patients benefit from this procedure by salvage of limbs from a loss by amputation. 

Measurements of overall reaction rates (of product formation or of reactant consumption) do not necessarily provide sufficient information to describe completely and unambiguously the kinetics of the constituent steps of a composite rate process. A nucleation and growth reaction, for example, is composed of the interlinked but distinct and different changes which lead to the initial generation and to the subsequent advance of the reaction interface. Quantitative kinetic analysis of yield—time data does not always lead to a unique reaction model but, in favourable systems, the rate parameters, considered with reference to quantitative microscopic measurements, can be identified with specific nucleation and growth steps. Microscopic examinations provide positive evidence for interpretation of shapes of fractional decomposition (a)—time curves. In reactions of solids, it is often convenient to consider separately the geometry of interface development and the chemical changes which occur within that zone of locally enhanced reactivity. 

---